Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.48 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.47 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.47 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | PTPRF | P10586 | 1/20 | 0.47 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1226181 | 0.90 | HTR6 (0.50) | HTTMEN1KMT2APOLBMAPT | |
| SCHEMBL20129851 | 0.86 | TSHR (0.59) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL20129837 | 0.85 | HTR6 (0.60) | MEN1KMT2APOLBMAPTLMNA | |
| SCHEMBL17761678 | 0.85 | HTR6 (0.45) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL8966735 | 0.85 | FFAR1 (0.47) | MEN1KMT2APOLBMAPTALDH1A1 | |
| SCHEMBL31577304 | 0.82 | MAPT (0.64) | HTTMEN1KMT2AMAPTLMNA | |
| SCHEMBL18600198 | 0.80 | PTPRF (0.71) | HTTMEN1KMT2APOLBMAPT | |
| SCHEMBL8966029 | 0.80 | MAPT (0.47) | HTTMEN1KMT2APOLBMAPT | |
| SCHEMBL1226537 | 0.80 | KCNQ3 (0.54) | MEN1KMT2AMAPTLMNAALDH1A1 | |
| SCHEMBL2470791 | 0.79 | HTR6 (0.59) | HTTMEN1KMT2APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9102593-B2 | Process for the preparation of retigabine | GLAXO GROUP LIMITED (GB) | 2015-08-11 | — | — | US | claimed |
| US-20130345465-A1 | PROCESS FOR THE PREPARATION OF RETIGABINE | GLAXO GROUP LIMITED (GB) | 2013-12-26 | — | — | US | claimed |
| EP-2665702-A1 | PROCESS FOR THE PREPARATION OF RETIGABINE | Glaxo Group Limited (GB) | 2013-11-27 | — | — | EP | claimed |
| WO-2012098075-A1 | PROCESS FOR THE PREPARATION OF RETIGABINE | GLAXO GROUP LIMITED (GB) | 2012-07-26 | — | — | WO | claimed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| EP-2772481-B1 | NOVEL COMPOUND AS KCNQ POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2017-01-18 | — | — | EP | disclosed |
| US-9353048-B2 | Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-31 | — | — | US | disclosed |
| US-9353048-B2 | Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-31 | — | — | US | disclosed |
| WO-2016077724-A1 | (2-AMINO-4(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | WO | disclosed |
| WO-2016077724-A1 | (2-AMINO-4(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | WO | disclosed |
| US-20120288544-A1 | NOVEL RETIGABINE COMPOSITION | GLAXO GROUP LIMITED (GB) | 2012-11-15 | — | — | US | disclosed |
| WO-2012098075-A1 | PROCESS FOR THE PREPARATION OF RETIGABINE | GLAXO GROUP LIMITED (GB) | 2012-07-26 | — | — | WO | disclosed |
| WO-2012098075-A1 | PROCESS FOR THE PREPARATION OF RETIGABINE | GLAXO GROUP LIMITED (GB) | 2012-07-26 | — | — | WO | disclosed |
| WO-2011101456-A2 | STABILIZED PHENYLCARBAMATE DERIVATIVE IN SOLID STATE | MEDICHEM S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011101456-A2 | STABILIZED PHENYLCARBAMATE DERIVATIVE IN SOLID STATE | MEDICHEM S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |
| EP-0554543-B1 | 1,2,4-Triaminobenzene derivatives and process for their preparation | ASTA MEDICA AG (DE) | 1996-02-28 | — | — | EP | disclosed |
| US-5384330-A | Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositions containing them | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-01-24 | — | — | US | disclosed |
| EP-0554543-A2 | 1,2,4-Triaminobenzene derivatives and process for their preparation | ASTA Medica Aktiengesellschaft (DE) | 1993-08-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120288544-A1 | NOVEL RETIGABINE COMPOSITION | CNR2, CNR1, CACNA1B | HTT 2034/4885MEN1 2976/4885KMT2A 360/4885 |
| US-20130345465-A1 | PROCESS FOR THE PREPARATION OF RETIGABINE | KCNB1, CYP4B1, KDM2B | HTT 3077/4885MEN1 3313/4885KMT2A 212/4885 |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | HRH4, H1-10, HDAC10 | HTT 64/4885MEN1 1794/4885KMT2A 811/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.