Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNQ3 | O43525 | 1/20 | 0.54 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.54 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.54 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.54 |
| ▸ | PPARA | Q07869 | 3/20 | 0.48 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.48 |
| ▸ | KCNH3 | Q9ULD8 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.45 |
| ▸ | NOS1 | P29475 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ARG1 | P05089 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13829230 | 0.85 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNQ4KCNQ5PPARA | |
| SCHEMBL16625703 | 0.85 | KCNQ3 (0.57) | KCNQ3KCNQ2KCNQ4KCNQ5PPARA | |
| SCHEMBL31577309 | 0.81 | FFAR1 (0.51) | PPARA | |
| SCHEMBL10055033 | 0.80 | LMNA (0.61) | KCNH3LMNAP4HTMGAAMEN1 | |
| SCHEMBL6419238 | 0.80 | LMNA (0.61) | KCNH3LMNAP4HTMGAAMEN1 | |
| SCHEMBL2236853 | 0.80 | HTT (0.49) | KCNQ3KCNQ2KCNQ4KCNQ5LMNA | |
| SCHEMBL15996872 | 0.79 | LMNA (0.53) | KCNQ3KCNQ2KCNQ4KCNQ5PPARA | |
| SCHEMBL11936055 | 0.79 | LMNA (0.53) | KCNQ3KCNQ2KCNQ4KCNQ5PPARA | |
| SCHEMBL1226181 | 0.79 | HTR6 (0.50) | KCNQ3KCNQ2KCNQ4KCNQ5LMNA | |
| SCHEMBL3901268 | 0.78 | KCNQ3 (0.54) | KCNQ3KCNQ2KCNQ4KCNQ5PPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103288653-A | Method for preparing 4-(4-fluorine benzyl amino)-1,2-phenylenediamine | ANHUI WANBANG MEDICAL TECHNOLOGY CO LTD | 2013-09-11 | — | — | CN | claimed |
| US-20200399196-A1 | Hydrogen Bond Directed Photocatalytic Hydrodefluorination and Methods of Use Thereof | UNIV OKLAHOMA STATE (US) | 2020-12-24 | — | — | US | disclosed |
| WO-2018187336-A1 | HYDROGEN BOND DIRECTED PHOTOCATALYTIC HYDRODEFLUORINATION AND METHODS OF USE THEREOF | THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY (US) | 2018-10-11 | — | — | WO | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2018-05-10 | — | — | US | disclosed |
| EP-2772481-B1 | NOVEL COMPOUND AS KCNQ POTASSIUM CHANNEL AGONIST, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI INST MATERIA MEDICA CAS (CN) | 2017-01-18 | — | — | EP | disclosed |
| US-9353048-B2 | Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-31 | — | — | US | disclosed |
| US-9353048-B2 | Compound as KCNQ potassium channel agonist, preparation method therefor and use thereof | SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES (CN) | 2016-05-31 | — | — | US | disclosed |
| WO-2016077724-A1 | (2-AMINO-4(ARYLAMINO)PHENYL) CARBAMATES | UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2016-05-19 | — | — | WO | disclosed |
| EP-2536394-A2 | STABILIZED PHENYLCARBAMATE DERIVATIVE IN SOLID STATE | Medichem S.A. (ES) | 2012-12-26 | — | — | EP | disclosed |
| WO-2011101456-A2 | STABILIZED PHENYLCARBAMATE DERIVATIVE IN SOLID STATE | MEDICHEM S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011101456-A2 | STABILIZED PHENYLCARBAMATE DERIVATIVE IN SOLID STATE | MEDICHEM S.A. (ES) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011012659-A2 | DIETHYL 4-(4-FLUOROBENZYLAMINO)-1,2-PHENYLENEDICARBAMATE, AND SALTS THEREOF | MEDICHEM S.A. (ES) | 2011-02-03 | — | — | WO | disclosed |
| WO-2011012659-A2 | DIETHYL 4-(4-FLUOROBENZYLAMINO)-1,2-PHENYLENEDICARBAMATE, AND SALTS THEREOF | MEDICHEM S.A. (ES) | 2011-02-03 | — | — | WO | disclosed |
| CN-101921195-A | Simple method for synthesizing intermediate of retigabine | BEIJING D VENTURE PHARM TECH | 2010-12-22 | — | — | CN | disclosed |
| CN-101921195-A | Simple method for synthesizing intermediate of retigabine | BEIJING D VENTURE PHARM TECH | 2010-12-22 | — | — | CN | disclosed |
| EP-1414791-A1 | METHOD FOR THE PRODUCTION OF 1,2,4-TRIAMINOBENZOLECARBAMIC ACID ESTERS | VIATRIS GmbH & Co. KG (DE) | 2004-05-06 | — | — | EP | disclosed |
| WO-2003010134-A1 | METHOD FOR THE PRODUCTION OF 1,2,4-TRIAMINOBENZOLECARBAMIC ACID ESTERS | VIATRIS GMBH & CO. KG (DE) | 2003-02-06 | — | — | WO | disclosed |
| US-20030023111-A1 | Process for the production of 1,2,4-triaminobenzene carbamic acid esters | XCEL PHARMACEUTICALS, INC. | 2003-01-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030023111-A1 | Process for the production of 1,2,4-triaminobenzene carbamic acid esters | CPS1, OTUB1, CYP4B1 | KCNQ3 3294/4885KCNQ2 2659/4885KCNQ4 2079/4885 |
| US-20180127357-A1 | (2-AMINO-4-(ARYLAMINO)PHENYL) CARBAMATES | HRH4, H1-10, HDAC10 | KCNQ3 1235/4885KCNQ2 1257/4885KCNQ4 1297/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.