Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 5/20 | 0.63 |
| ▸ | BRD4 | O60885 | 4/20 | 0.63 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.41 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 5/20 | 0.38 |
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.38 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28566657 | 0.82 | CREBBP (0.62) | CREBBPBRD4KCNH2SCN3AS1PR5 | |
| SCHEMBL17673118 | 0.77 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL17673303 | 0.77 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL27898293 | 0.67 | BRD4 (0.47) | CREBBPBRD4KCNH2SCN3AS1PR5 | |
| SCHEMBL22368922 | 0.67 | CREBBP (0.72) | CREBBPBRD4KCNH2SCN3AS1PR5 | |
| SCHEMBL22368830 | 0.67 | CREBBP (0.72) | CREBBPBRD4KCNH2SCN3AS1PR5 | |
| SCHEMBL6904351 | 0.66 | FFAR1 (0.61) | KCNH2SCN3AS1PR5S1PR1FFAR1 | |
| SCHEMBL28555707 | 0.66 | BRD4 (0.62) | CREBBPBRD4KCNH2SCN3AS1PR5 | |
| SCHEMBL5715746 | 0.64 | FFAR1 (0.51) | CREBBPBRD4FFAR1ALOX5LTB4R | |
| SCHEMBL22369023 | 0.64 | BRD4 (0.52) | CREBBPBRD4KCNH2SCN3AS1PR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |