Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 3/20 | 0.59 |
| ▸ | CREBBP | Q92793 | 3/20 | 0.59 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | F2R | P25116 | 1/20 | 0.41 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.41 |
| ▸ | RHOA | P61586 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | CASR | P41180 | 1/20 | 0.39 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | LCLAT1 | Q6UWP7 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17680684 | 0.84 | CREBBP (0.71) | BRD4CREBBPBRAFF2RIMPDH2 | |
| SCHEMBL22368807 | 0.76 | CREBBP (0.73) | BRD4CREBBPBRAFF2RIMPDH2 | |
| SCHEMBL22360968 | 0.75 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL17680753 | 0.75 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL17680591 | 0.75 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL17680680 | 0.74 | CREBBP (0.82) | BRD4CREBBPBRAFF2RIMPDH2 | |
| SCHEMBL17680615 | 0.71 | CREBBP (1.00) | BRD4CREBBP | |
| SCHEMBL16238452 | 0.71 | IMPDH2 (0.61) | BRD4CREBBPBRAFIMPDH2KDM4E | |
| SCHEMBL11926134 | 0.70 | BRAF (0.73) | BRD4CREBBPBRAFIMPDH2NPC1 | |
| SCHEMBL22369018 | 0.69 | CREBBP (0.77) | BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |