Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.39 |
| ▸ | CA2 | P00918 | 3/20 | 0.39 |
| ▸ | CA4 | P22748 | 3/20 | 0.39 |
| ▸ | CA9 | Q16790 | 3/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | FABP3 | P05413 | 5/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Silver SCHEMBL2239077 | 0.92 | CA1 (0.38) | CA1CA12CA2CA4CA9 | |
| SCHEMBL14894607 | 0.82 | ALDH1A1 (0.52) | FABP3 | |
| SCHEMBL2011072 | 0.82 | ALDH1A1 (0.52) | FABP3 | |
| SCHEMBL2011462 | 0.82 | ALDH1A1 (0.52) | FABP3 | |
| SCHEMBL398562 | 0.82 | ALDH1A1 (0.52) | FABP3 | |
| SCHEMBL2011728 | 0.82 | ALDH1A1 (0.52) | FABP3 | |
| SCHEMBL2010277 | 0.82 | ALDH1A1 (0.52) | FABP3 | |
| SCHEMBL25184217 | 0.80 | CA12 (0.50) | CA1CA12CA2CA4CA9 | |
| SCHEMBL8957343 | 0.80 | CA12 (0.50) | CA1CA12CA2CA4CA9 | |
| SCHEMBL25180691 | 0.80 | CA12 (0.50) | CA1CA12CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011101245-A1 | NITRIC OXIDE RELEASING COMPOUNDS FOR THE TREATMENT OF NEUROPATHIC PAIN | NICOX S.A. (FR) | 2011-08-25 | — | — | WO | disclosed |
| WO-2011092065-A1 | NITRIC OXIDE RELEASING COMPOUNDS FOR THE TREATMENT OF NEUROPHATIC PAIN | NICOX S.A. (FR) | 2011-08-04 | — | — | WO | disclosed |