Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 14/20 | 0.70 |
| ▸ | BRD4 | O60885 | 12/20 | 0.70 |
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22368733 | 0.89 | CREBBP (0.69) | CREBBPBRD4BRD2CRBNNPC1 | |
| SCHEMBL17680617 | 0.82 | CREBBP (1.00) | CREBBPBRD4 | |
| SCHEMBL22368600 | 0.82 | CREBBP (0.68) | CREBBPBRD4CRBNGAAMAPT | |
| SCHEMBL22368888 | 0.81 | CREBBP (0.66) | CREBBPBRD4 | |
| SCHEMBL22369263 | 0.79 | CREBBP (0.48) | CREBBPBRD4 | |
| SCHEMBL22368597 | 0.79 | CREBBP (0.61) | CREBBPBRD4NPC1MAPTRAB9A | |
| SCHEMBL22368642 | 0.78 | CREBBP (0.48) | CREBBPBRD4 | |
| SCHEMBL17680917 | 0.78 | CREBBP (0.48) | CREBBPBRD4CRBNLMNASMN1; SMN2 | |
| SCHEMBL22369321 | 0.77 | CREBBP (0.59) | CREBBPBRD4NPC1LMNATP53 | |
| SCHEMBL17680925 | 0.76 | CREBBP (0.65) | CREBBPBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3204360-B1 | THERAPEUTIC COMPOUNDS AND USES THEREOF | GENENTECH INC (US) | 2020-08-26 | — | — | EP | disclosed |
| US-9453027-B2 | Deuterium-enriched pyridinonecarboxamides and derivatives | DHANOA DALJIT SINGH (US) | 2016-09-27 | — | — | US | disclosed |