⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18513346 | 0.84 | ATM (0.33) | — | |
| SCHEMBL25492845 | 0.84 | MMP2 (0.33) | — | |
| SCHEMBL22996017 | 0.84 | MMP2 (0.33) | — | |
| SCHEMBL24375001 | 0.84 | ATM (0.33) | — | |
| SCHEMBL23710651 | 0.82 | HCRTR2 (0.35) | — | |
| SCHEMBL18513313 | 0.82 | HCRTR2 (0.35) | — | |
| SCHEMBL24098413 | 0.81 | HCRTR2 (0.31) | — | |
| SCHEMBL24646128 | 0.80 | — | — | |
| SCHEMBL23136552 | 0.80 | HCRTR2 (0.32) | — | |
| SCHEMBL18972588 | 0.78 | ATM (0.45) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220324900-A1 | COMPOSITIONS AND METHODS FOR MODULATING ANGIOPOIETIN-LIKE 3 EXPRESSION | IONIS PHARMACEUTICALS, INC. (US) | 2022-10-13 | — | — | US | disclosed |
| US-20200270609-A1 | Single-Stranded RNAI Oligonucleotides Targeting APOC-III | IONIS PHARMACEUTICALS, INC. (US) | 2020-08-27 | — | — | US | disclosed |