Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | MLLT1 | Q03111 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.34 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 2/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.33 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12346719 | 0.95 | SMN1; SMN2 (0.40) | MAPTCRHBPCRHR2SMN1; SMN2MLLT1 | |
| Trifluoroacetic Acid SCHEMBL2243218 | 0.89 | TSHR (0.42) | MLLT1TSHRALDH1A1KMT2ACACNA1G | |
| Trifluoroacetic Acid SCHEMBL2238818 | 0.89 | TSHR (0.42) | MLLT1TSHRALDH1A1KMT2ACACNA1G | |
| Trifluoroacetic Acid SCHEMBL2234999 | 0.88 | TSHR (0.43) | SMN1; SMN2SLC2A1MLLT1TSHRALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL302268 | 0.84 | TSHR (0.38) | BDKRB1TSHRKMT2ACACNA1GCXCR3 | |
| SCHEMBL2238958 | 0.84 | TSHR (0.47) | MAPTSMN1; SMN2MLLT1BDKRB1TSHR | |
| SCHEMBL12346720 | 0.84 | TSHR (0.47) | MAPTSMN1; SMN2MLLT1TSHRALDH1A1 | |
| SCHEMBL12346722 | 0.84 | TSHR (0.47) | MAPTSMN1; SMN2MLLT1TSHRALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL2238388 | 0.83 | ALDH1A1 (0.38) | MAPTSLC2A1TSHRALDH1A1KMT2A | |
| SCHEMBL12346715 | 0.83 | TSHR (0.47) | MAPTSMN1; SMN2MLLT1BDKRB1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | claimed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | claimed |
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| US-8623859-B2 | Bradykinin B1 antagonists | EVOTEC AG (DE) | 2014-01-07 | — | — | US | disclosed |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | MAPT 2733/4885CRHBP 628/4885CRHR2 243/4885 |
| US-20110201589-A1 | NEW BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | MAPT 2466/4885CRHBP 670/4885CRHR2 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.