SCHEMBL223893

SCHEMBL223893

Cc1c(F)ccc(C#N)c1F

nearest known ligand 0.42

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
AR P10275 6/20 0.42
TRPV4 Q9HBA0 2/20 0.42
EGLN2 Q96KS0 2/20 0.41
CYP11B1 P15538 4/20 0.39
CYP11B2 P19099 4/20 0.39
TSHR P16473 1/20 0.38
USP8 P40818 1/20 0.37
USP7 Q93009 1/20 0.37
ESR1 P03372 1/20 0.36
ESR2 Q92731 1/20 0.36
TDP1 Q9NUW8 1/20 0.35
L3MBTL1 Q9Y468 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13216259 0.86 AR (0.44) ARTRPV4EGLN2CYP11B1CYP11B2
SCHEMBL2693449 0.84 AR (0.47) ARTRPV4CYP11B1CYP11B2TSHR
SCHEMBL13199476 0.82 TSHR (0.43) ARTRPV4EGLN2CYP11B1CYP11B2
SCHEMBL6364089 0.82 TRPV4 (0.42) ARTRPV4CYP11B1CYP11B2TSHR
SCHEMBL24075906 0.78 AR (0.41) ARTRPV4EGLN2CYP11B2TSHR
SCHEMBL31673035 0.78 ESR1 (0.41) ARTRPV4CYP11B1CYP11B2TSHR
SCHEMBL20954185 0.78 TRPV4 (0.39) ARTRPV4CYP11B1CYP11B2TSHR
SCHEMBL31171401 0.78 AR (0.41) ARTRPV4EGLN2CYP11B2TSHR
SCHEMBL152425 0.78 AR (0.40) ARTRPV4EGLN2CYP11B1CYP11B2
SCHEMBL152108 0.78 EGLN2 (0.43) ARTRPV4EGLN2CYP11B1CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12577231-B2 Androgen receptor PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-03-17 US disclosed
US-20260001865-A1 ANDROGEN RECEPTOR PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2026-01-01 US disclosed
WO-2025061906-A1 ANDROGEN RECEPTOR PROTACS GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) 2025-03-27 WO disclosed
US-20250100981-A1 Cis-substituted 5-(hydroxymethyl)morpholine-2-carboxamides as agonists of SSTR4 BOEHRINGER INGELHEIM INT (DE) 2025-03-27 US disclosed
WO-2025049939-A1 SELECTIVE ANDROGEN RECEPTOR MODULATOR BASED RADIOPHARMACEUTICALS FOR IMAGING ANDROGEN RECEPTOR MEMORIAL SLOAN-KETTERING CANCER CENTER (US) 2025-03-06 WO disclosed
WO-2025027049-A1 (2S,5R)-5-(HYDROXYMETHYL)MORPHOLINE-2-CARBOXAMIDES AS AGONISTS OF SSTR4 BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2025-02-06 WO disclosed
WO-2024211969-A1 PPARG MODULATORS Setonix Pharmaceuticals Pty Ltd (AU) 2024-10-17 WO disclosed
US-11518764-B2 Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) 2022-12-06 US disclosed
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof LIGAND PHARMACEUTICALS INCORPORATED (US) 2022-06-14 US disclosed
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF CITIBANK, N.A., AS ADMINISTRATIVE AGENT 2020-11-19 US disclosed
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED 2010-10-07 US disclosed
EP-2222636-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF Ligand Pharmaceuticals Inc. (US) 2010-09-01 EP disclosed
WO-2009082437-A9 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2010-08-12 WO disclosed
EP-2176220-A2 PYRROLIDIN-2-ONE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR Takeda Pharmaceutical Company Limited (JP) 2010-04-21 EP disclosed
US-20100087506-A1 CYCLIC AMINE COMPOUND TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2010-04-08 US disclosed
EP-2098507-A1 CYCLIC AMINE COMPOUND Takeda Pharmaceutical Company Limited (JP) 2009-09-09 EP disclosed
WO-2009082437-A2 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF LIGAND PHARMACEUTICALS INCORPORATED (US) 2009-07-02 WO disclosed
WO-2009020234-A2 PYRROLIDIN-2 -ONE DERIVATIVES AS ANDROGEN RECEPTOR MODULATOR TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-02-12 WO disclosed
US-20090042967-A1 Cyclic amine compounds TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2009-02-12 US disclosed
US-20050054733-A1 Difluoroalkylaromatics LANXESS DEUTSCHLAND GMBH (DE) 2005-03-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11518764-B2 Substituted heteroaryls as inhibitors of the BCL6 BTB domain protein-protein interaction BCL6, BCL6B, BCL3 AR 1375/4885TRPV4 4510/4885EGLN2 1011/4885
US-20200361866-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885TRPV4 1287/4885EGLN2 2332/4885
US-20100256129-A1 SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS) AND USES THEREOF AR, NR5A1, SHBG AR 1/4885TRPV4 1604/4885EGLN2 1545/4885
US-11358931-B2 Selective androgen receptor modulators (SARMs) and uses thereof AR, NR5A1, SHBG AR 1/4885TRPV4 1424/4885EGLN2 2001/4885
US-20260001865-A1 ANDROGEN RECEPTOR PROTACS AR, CRBN, PSMA3 AR 1/4885TRPV4 4281/4885EGLN2 2213/4885
US-12577231-B2 Androgen receptor PROTACS AR, CRBN, PSMA3 AR 1/4885TRPV4 4281/4885EGLN2 2213/4885
US-20090042967-A1 Cyclic amine compounds SHBG, FSHR, ACP3 AR 4/4885TRPV4 3417/4885EGLN2 476/4885
US-20050054733-A1 Difluoroalkylaromatics NQO1, TYR, FLI1 AR 2057/4885TRPV4 3436/4885EGLN2 2097/4885
US-20250100981-A1 Cis-substituted 5-(hydroxymethyl)morpholine-2-carboxamides as agonists of SSTR4 SSTR4, SSTR5, SSTR2 AR 428/4885TRPV4 250/4885EGLN2 1493/4885
US-20100087506-A1 CYCLIC AMINE COMPOUND AR, FSHR, NR5A1 AR 1/4885TRPV4 1687/4885EGLN2 545/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.