Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 8/20 | 0.57 |
| ▸ | TDO2 | P48775 | 8/20 | 0.57 |
| ▸ | EIF4A3 | P38919 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | RHEB | Q15382 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29946325 | 1.00 | IDO1 (0.57) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL20505497 | 0.84 | EIF4A3 (0.51) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL30798739 | 0.84 | EIF4A3 (0.44) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL26312516 | 0.84 | IDO1 (0.41) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL30067353 | 0.84 | IDO1 (0.41) | IDO1TDO2EIF4A3GRIN1RHEB | |
| SCHEMBL30544758 | 0.84 | IDO1 (0.41) | IDO1TDO2EIF4A3RHEB | |
| SCHEMBL26292257 | 0.82 | GPR35 (0.56) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL22747188 | 0.81 | IDO1 (0.75) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL29974758 | 0.81 | IDO1 (0.75) | IDO1TDO2EIF4A3HPGDKDM4E | |
| SCHEMBL20505539 | 0.80 | KDM4E (0.63) | IDO1TDO2EIF4A3HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116396204-A | Preparation method of 4,6,7-trifluoro-1H-indole-2-carboxylic acid | 无锡科华生物科技有限公司 | 2023-07-07 | — | — | CN | claimed |
| US-20260138988-A1 | Spiropyrrolidine Derived Antiviral Agents | ENANTA PHARMACEUTICALS INC (US) | 2026-05-21 | — | — | US | disclosed |
| US-12479854-B2 | Spiropyrrolidine derived antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2025-11-25 | — | — | US | disclosed |
| US-12398147-B2 | Macrocyclic spiropyrrolidine derived antiviral agents | ENANTA PHARMACEUTICALS, INC. (US) | 2025-08-26 | — | — | US | disclosed |
| WO-2025101881-A1 | HETEROATOM CONTAINING PEPTIDOMIMETICS TARGETING VIRAL PROTEASES | EMORY UNIVERSITY (US) | 2025-05-15 | — | — | WO | disclosed |
| CN-116396204-B | Preparation method of 4,6, 7-trifluoro-1H-indole-2-carboxylic acid | 无锡科华生物科技有限公司 | 2024-09-24 | — | — | CN | disclosed |
| US-20240199647-A1 | ANTI-VIRAL COMPOUNDS | KATHOLIEKE UNIVERSITEIT LEUVEN (BE) | 2024-06-20 | — | — | US | disclosed |
| CN-118165069-A | Nitrogen-containing spiro indoline compound, and preparation method and application thereof | 深圳信立泰药业股份有限公司 | 2024-06-11 | — | — | CN | disclosed |
| US-12006291-B2 | Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid | ENANTA PHARMACEUTICALS, INC. (US) | 2024-06-11 | — | — | US | disclosed |
| US-12006291-B2 | Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid | ENANTA PHARMACEUTICALS, INC. (US) | 2024-06-11 | — | — | US | disclosed |
| US-20210179608-A1 | NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2021-06-17 | — | — | US | disclosed |
| US-20200354379-A1 | NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-12 | — | — | US | disclosed |
| US-20200354379-A1 | NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-12 | — | — | US | disclosed |
| WO-2020221811-A1 | NOVEL OXALYL PIPERAZINES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-05 | — | — | WO | disclosed |
| WO-2020221826-A1 | NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-05 | — | — | WO | disclosed |
| WO-2020221826-A1 | NOVEL INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AICURIS GMBH & CO. KG (DE) | 2020-11-05 | — | — | WO | disclosed |
| EP-3704127-A1 | NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2020-09-09 | — | — | EP | disclosed |
| EP-3704119-A1 | NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | AiCuris GmbH & Co. KG (DE) | 2020-09-09 | — | — | EP | disclosed |
| CN-111527087-A | Novel highly active pyrazolo-piperidine substituted indole-2-carboxamides having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2020-08-11 | — | — | CN | disclosed |
| CN-111448199-A | Novel highly active amino-thiazole-substituted indole-2-carboxamides having activity against Hepatitis B Virus (HBV) | 艾库里斯有限及两合公司 | 2020-07-24 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20260138988-A1 | Spiropyrrolidine Derived Antiviral Agents | ACE, ACE2, TMPRSS2 | IDO1 2679/4885TDO2 3256/4885EIF4A3 1533/4885 |
| US-20210179608-A1 | NOVEL, HIGHLY ACTIVE PYRAZOLO-PIPERIDINE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | CDK2, HCCS, BRD4 | IDO1 30/4885TDO2 850/4885EIF4A3 810/4885 |
| US-12398147-B2 | Macrocyclic spiropyrrolidine derived antiviral agents | ACE, ACE2, PKD1 | IDO1 1621/4885TDO2 4795/4885EIF4A3 110/4885 |
| US-12479854-B2 | Spiropyrrolidine derived antiviral agents | ACE, ACE2, PKD1 | IDO1 1295/4885TDO2 4738/4885EIF4A3 582/4885 |
| US-12006291-B2 | Processes for the preparation of 4,6,7-trifluoro-1H-indole-2-carboxylic acid | ACE2, HTR3C, SARS1 | IDO1 5/4885TDO2 25/4885EIF4A3 421/4885 |
| US-20200354379-A1 | NOVEL, HIGHLY ACTIVE AMINO-THIAZOLE SUBSTITUTED INDOLE-2-CARBOXAMIDES ACTIVE AGAINST THE HEPATITIS B VIRUS (HBV) | HCCS, CDK2, BRD4 | IDO1 14/4885TDO2 210/4885EIF4A3 783/4885 |
| US-20240199647-A1 | ANTI-VIRAL COMPOUNDS | EIF2AK2, ZC3HAV1, HAVCR2 | IDO1 3030/4885TDO2 4808/4885EIF4A3 195/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.