Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.48 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15989875 | 1.00 | MEN1 (0.54) | MEN1KMT2ASLC6A2HTR2ASLC6A4 | |
| SCHEMBL22612421 | 1.00 | MEN1 (0.54) | MEN1KMT2ASLC6A2HTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL31752444 | 0.98 | MEN1 (0.52) | MEN1KMT2ASLC6A2HTR2ASLC6A4 | |
| Hydrochloric Acid SCHEMBL31303042 | 0.98 | MEN1 (0.52) | MEN1KMT2ASLC6A2HTR2ASLC6A4 | |
| SCHEMBL8760835 | 0.82 | SLC6A2 (0.48) | MEN1KMT2ASLC6A2HTR2ASLC6A4 | |
| SCHEMBL7837799 | 0.81 | ESR1 (0.56) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL8891278 | 0.81 | LMNA (0.56) | MEN1KMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL17018523 | 0.79 | TSHR (0.50) | SLC6A2SLC6A4SLC6A3TSHRCYP19A1 | |
| SCHEMBL11319289 | 0.79 | MEN1 (0.56) | MEN1KMT2ASLC6A2HTR2ASLC6A4 | |
| SCHEMBL1807039 | 0.79 | MEN1 (0.56) | MEN1KMT2ASLC6A2HTR2ASLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3704091-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |