Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2011901 | 0.85 | APP (0.48) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 | |
| SCHEMBL31410551 | 0.84 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 | |
| SCHEMBL31198109 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 | |
| SCHEMBL31198080 | 0.81 | SLC6A2 (0.40) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 | |
| SCHEMBL10914361 | 0.80 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CASP1SMN1; SMN2 | |
| SCHEMBL10914355 | 0.80 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3CASP1SMN1; SMN2 | |
| SCHEMBL31410641 | 0.79 | PPARA (0.39) | SLC6A2SLC6A4SLC6A3FFAR1SMN1; SMN2 | |
| SCHEMBL1932881 | 0.79 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 | |
| SCHEMBL29743262 | 0.79 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 | |
| SCHEMBL28017230 | 0.79 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3FFAR1PSEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200347033-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC | 2020-11-05 | — | — | US | disclosed |
| EP-3704091-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347033-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | ATF4, ATF1, IRF3 | SLC6A2 1702/4885SLC6A4 1953/4885SLC6A3 3305/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.