Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.31 |
| ▸ | CCR8 | P51685 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22402165 | 0.86 | CYP2D6 (0.41) | DPP8DPP9HTR1ANAMPTAVPR1A | |
| SCHEMBL22958207 | 0.80 | TSHR (0.36) | HTR1AKDM4EAVPR1AHRH3KCNH2 | |
| SCHEMBL22520496 | 0.80 | NAMPT (0.32) | HTR1ANAMPT | |
| SCHEMBL30486552 | 0.76 | SIGMAR1 (0.38) | ALDH1A1AVPR1AHRH3CCR8KCNH2 | |
| SCHEMBL30486670 | 0.76 | AVPR1A (0.35) | ALDH1A1MEN1KMT2AAVPR1A | |
| SCHEMBL27454475 | 0.76 | AVPR1A (0.35) | ALDH1A1MEN1KMT2AAVPR1A | |
| SCHEMBL23509314 | 0.75 | GRIN2D (0.41) | ALDH1A1MEN1KMT2AAVPR1AKCNH2 | |
| SCHEMBL30486564 | 0.75 | HSD17B10 (0.33) | ALDH1A1AVPR1ADRD2DRD3 | |
| SCHEMBL27454457 | 0.75 | AVPR1A (0.33) | ALDH1A1MEN1KMT2AAVPR1A | |
| SCHEMBL20651754 | 0.73 | DPP8 (0.51) | DPP8DPP9NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11033547-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | MERCK PATENT GMBH (DE) | 2021-06-15 | — | — | US | disclosed |
| US-20200281926-A1 | CARBOXAMIDE-PYRIMIDINE DERIVATIVES AS SHP2 ANTAGONISTS | MERCK PATENT GMBH (DE) | 2020-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11033547-B2 | Carboxamide-pyrimidine derivatives as SHP2 antagonists | PTPN5, PTPN2, PTPN1 | DPP8 1894/4885DPP9 1715/4885HTR1A 4127/4885 |
| US-20200281926-A1 | CARBOXAMIDE-PYRIMIDINE DERIVATIVES AS SHP2 ANTAGONISTS | PTPN5, PTPN2, PTPN1 | DPP8 1894/4885DPP9 1715/4885HTR1A 4127/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.