Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | SPR | P35270 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22958207 | 0.83 | TSHR (0.36) | SIGMAR1CHRM2KCNH2HRH3AVPR1A | |
| SCHEMBL27454475 | 0.81 | AVPR1A (0.35) | SIGMAR1AVPR1ASPRALDH1A1HPGD | |
| SCHEMBL30486670 | 0.81 | AVPR1A (0.35) | SIGMAR1AVPR1ASPRALDH1A1HPGD | |
| SCHEMBL29930648 | 0.79 | SPR (0.42) | CHRM2HRH3SPRALDH1A1HPGD | |
| SCHEMBL23509314 | 0.78 | GRIN2D (0.41) | CHRM2KCNH2AVPR1AALDH1A1HPGD | |
| SCHEMBL27454457 | 0.78 | AVPR1A (0.33) | AVPR1AALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL22402165 | 0.78 | CYP2D6 (0.41) | KCNH2CCR8OPRL1HRH3AVPR1A | |
| SCHEMBL30486564 | 0.78 | HSD17B10 (0.33) | AVPR1AALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL22402166 | 0.76 | DPP8 (0.37) | KCNH2CCR8HRH3AVPR1AALDH1A1 | |
| SCHEMBL21852080 | 0.74 | ALDH1A1 (0.45) | ALDH1A1HPGDHSD17B10SMN1; SMN2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4448526-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | GENZYME CORPORATION (US) | 2024-10-23 | — | — | EP | disclosed |
| WO-2023114954-A1 | PYRAZOLOPYRAZINE COMPOUNDS AS SHP2 INHIBITORS | GENZYME CORPORATION (US) | 2023-06-22 | — | — | WO | disclosed |