Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 4/20 | 0.42 |
| ▸ | RAF1 | P04049 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 7/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.40 |
| ▸ | NR2C2 | P49116 | 2/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.40 |
| ▸ | RELA | Q04206 | 2/20 | 0.40 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | HIPK4 | Q8NE63 | 2/20 | 0.38 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2246414 | 0.98 | CSF1R (0.42) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2246305 | 0.92 | RAF1 (0.43) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2246431 | 0.90 | KDR (0.42) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2244107 | 0.90 | BRAF (0.40) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2247968 | 0.88 | CSF1R (0.40) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2244176 | 0.88 | BRAF (0.44) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2243488 | 0.86 | BRAF (0.44) | BRAFRAF1CSF1RKDRNFKB1 | |
| SCHEMBL2241177 | 0.83 | MAPK14 (0.43) | BRAFRAF1CSF1RKDRMAPK14 | |
| SCHEMBL2243887 | 0.83 | HRH3 (0.36) | RAF1CSF1RKDRMAPK14 | |
| SCHEMBL2241233 | 0.82 | BRAF (0.42) | BRAFRAF1CSF1RKDRNFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110195110-A1 | UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER | BAYER HEALTHCARE LLC | 2011-08-11 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110195110-A1 | UREA COMPOUNDS USEFUL IN THE TREATMENT OF CANCER | UMPS, SLC14A1, CPS1 | BRAF 338/4885RAF1 860/4885CSF1R 4428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.