Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | KDR | P35968 | 12/20 | 0.45 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.45 |
| ▸ | CSF1R | P07333 | 9/20 | 0.44 |
| ▸ | PDGFRB | P09619 | 9/20 | 0.44 |
| ▸ | MET | P08581 | 3/20 | 0.44 |
| ▸ | AURKA | O14965 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.44 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | IGF1R | P08069 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 1/20 | 0.43 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.43 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22407551 | 0.90 | FGFR2 (0.53) | FGFR2KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL22407579 | 0.88 | MET (0.53) | FGFR2KDRPDGFRAMETIGF1R | |
| SCHEMBL22407446 | 0.88 | KDR (0.48) | FGFR2KDRPDGFRAMETAURKA | |
| SCHEMBL20775123 | 0.87 | FGFR2 (0.57) | FGFR2KDRPDGFRAMETAURKA | |
| SCHEMBL22407621 | 0.86 | KDR (0.45) | FGFR2KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL22407423 | 0.85 | AXL (0.46) | FGFR2KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL20782728 | 0.83 | AXL (0.52) | FGFR2KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL22407518 | 0.82 | FGFR2 (0.46) | FGFR2KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL22407328 | 0.81 | KDR (0.50) | FGFR2KDRPDGFRACSF1RPDGFRB | |
| SCHEMBL22407371 | 0.78 | KDR (0.51) | FGFR2KDRPDGFRACSF1RPDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ABBVIE INC (US) | 2023-06-15 | — | — | US | disclosed |
| US-20200291024-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ABBVIE INC (US) | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200291024-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, STING1 | FGFR2 4496/4885KDR 2584/4885PDGFRA 624/4885 |
| US-20230183239-A1 | ECTONUCLEOTIDE PYROPHOSPHATASE-PHOSPHODIESTERASE 1 (ENPP-1) INHIBITORS AND USES THEREOF | ENPP1, ENPP3, STING1 | FGFR2 4496/4885KDR 2584/4885PDGFRA 624/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.