Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 6/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.37 |
| ▸ | GPR55 | Q9Y2T6 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22409477 | 1.00 | ALDH1A1 (0.38) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL19014805 | 0.89 | ALDH1A1 (0.40) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL22409480 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL22409478 | 0.87 | KDM4E (0.41) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL22409430 | 0.86 | NPC1 (0.37) | ALDH1A1KDM4ENPC1RAB9AGPR55 | |
| SCHEMBL22409428 | 0.86 | NPC1 (0.37) | ALDH1A1KDM4ENPC1RAB9AGPR55 | |
| SCHEMBL22428656 | 0.81 | NPC1 (0.40) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL22409446 | 0.78 | MEN1 (0.41) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL22409448 | 0.78 | MEN1 (0.41) | ALDH1A1KDM4EMAOAMAOBNPC1 | |
| SCHEMBL19014628 | 0.78 | NPC1 (0.40) | ALDH1A1KDM4EMAOAMAOBNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11111259-B2 | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders | UNITY BIOTECHNOLOGY, INC. (US) | 2021-09-07 | — | — | US | disclosed |
| US-20200291050-A1 | ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS | UNITY BIOTECHNOLOGY, INC. | 2020-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11111259-B2 | Acylsulfonamide derivatives for treating senescence-associated diseases and disorders | ACAT1, ARSA, GLA | ALDH1A1 611/4885KDM4E 1998/4885MAOA 2775/4885 |
| US-20200291050-A1 | ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS | ACAT1, ARSA, GLA | ALDH1A1 611/4885KDM4E 1998/4885MAOA 2775/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.