Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.40 |
| ▸ | GNAO1 | P09471 | 6/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 5/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 5/20 | 0.39 |
| ▸ | CXCR4 | P61073 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SOD3 | P08294 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22415173 | 0.93 | POLB (0.41) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL22430327 | 0.91 | GNAO1 (0.45) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL23132579 | 0.89 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL18773834 | 0.89 | GNAO1 (0.46) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL27811670 | 0.85 | POLB (0.38) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL9236820 | 0.84 | GNAO1 (0.47) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL21361983 | 0.83 | HRH3 (0.38) | GNAO1GNAI3GNAI1CHRM2CHRM1 | |
| SCHEMBL21348729 | 0.82 | CXCR4 (0.43) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL17526835 | 0.81 | CXCR4 (0.40) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 | |
| SCHEMBL17526564 | 0.81 | CXCR4 (0.40) | SIGMAR1GNAO1GNAI3GNAI1CXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3705474-A1 | PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF ACUTE MYELOID LEUKEMIA OR METASTATIC BREAST CANCER | Pelemed Co., Ltd. (KR) | 2020-09-09 | — | — | EP | disclosed |