Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.43 |
| ▸ | GNAO1 | P09471 | 5/20 | 0.39 |
| ▸ | GNAI3 | P08754 | 4/20 | 0.39 |
| ▸ | GNAI1 | P63096 | 4/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | SOD3 | P08294 | 2/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27811670 | 0.89 | POLB (0.38) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL17526835 | 0.88 | CXCR4 (0.40) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL17526564 | 0.88 | CXCR4 (0.40) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL17526735 | 0.88 | CXCR4 (0.42) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL17526641 | 0.88 | CXCR4 (0.42) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL15187302 | 0.86 | LMNA (0.41) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL15187305 | 0.86 | LMNA (0.41) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL17524044 | 0.85 | CXCR4 (0.40) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL17524042 | 0.85 | CXCR4 (0.40) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 | |
| SCHEMBL9236820 | 0.84 | GNAO1 (0.47) | CXCR4GNAO1GNAI3GNAI1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | YALE UNIVERSITY (US) | 2021-04-06 | — | — | US | disclosed |
| US-20190276425-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | UNIV YALE (US) | 2019-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10968198-B2 | Biaryltriazole inhibitors of macrophage migration inhibitory factor | MIF, MMP12, CSF1R | CXCR4 181/4885GNAO1 1401/4885GNAI3 112/4885 |
| US-20190276425-A1 | BIARYLTRIAZOLE INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR | MIF, MMP12, CSF1R | CXCR4 181/4885GNAO1 1401/4885GNAI3 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.