SCHEMBL22417872

SCHEMBL22417872

CC1(C)c2ccccc2N(c2ccc(Cc3c(Cc4ccc(N5c6ccccc6C(C)(C)c6ccccc65)cc4)c(-c4ccccc4)c(C#N)c(C#N)c3-c3ccccc3)cc2)c2ccccc21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 8/20 0.34
AR P10275 1/20 0.34
PGR P06401 1/20 0.34
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
FPR1 P21462 1/20 0.33
ALDH1A1 P00352 4/20 0.33
RXFP1 Q9HBX9 1/20 0.33
ITGB2 P05107 1/20 0.33
ICAM1 P05362 1/20 0.33
ITGAL P20701 1/20 0.33
MAPT P10636 3/20 0.32
NPSR1 Q6W5P4 2/20 0.32
GLA P06280 1/20 0.32
ATM Q13315 1/20 0.32
HTT P42858 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
TDP1 Q9NUW8 1/20 0.32
LMNA P02545 1/20 0.32
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17483346 0.85 GRIA4 (0.38) KDM4EARPGRCYP2C9ALDH1A1
SCHEMBL17483344 0.85 GRIA4 (0.38) KDM4EARPGRCYP2C9ALDH1A1
SCHEMBL17483390 0.82 PGR (0.39) KDM4EARPGRCYP3A4CYP2C9
SCHEMBL17883172 0.81 PGR (0.40) KDM4EARPGRCYP3A4CYP2C9
SCHEMBL22417748 0.79
SCHEMBL21414474 0.78 CYP1A2 (0.41) PGRCYP3A4CYP2C9ALDH1A1ITGB2
SCHEMBL17483442 0.77 PGR (0.42) KDM4EARPGRALDH1A1MAPT
SCHEMBL17850986 0.75 GRIA4 (0.33) KDM4EARPGRALDH1A1RXFP1
SCHEMBL21250623 0.74 HTR2A (0.34) KDM4EARPGRCYP2C9ALDH1A1
SCHEMBL19648909 0.74

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3706182-A1 ORGANIC ELECTROLUMINESCENT DEVICE Kyushu University National University Corporation (JP) 2020-09-09 EP disclosed