Sugi Predict

Sugi Predict / Compounds / Nocodazole

Nocodazole

Nocodazole

SCHEMBL22418403

COC(=O)Nc1nc2cc(C(=O)c3cccs3)ccc2[nH]1.C[S+](C)[O-]

nearest known ligand 0.76

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

MAP2K1MAP2K2

The experimentally established mechanism targets of Nocodazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ABL1 P00519 3/20 0.76
▸ ALDH1A1 P00352 2/20 0.76
▸ LMNA P02545 2/20 0.76
▸ CYP1A2 P05177 2/20 0.76
▸ CYP2C9 P11712 2/20 0.76
▸ HTT P42858 2/20 0.76
▸ HIF1A Q16665 2/20 0.76
▸ TUBB4A P04350 2/20 0.76
▸ TUBB P07437 2/20 0.76
▸ TUBA3C P0DPH7 2/20 0.76
▸ TUBA1B P68363 2/20 0.76
▸ TUBA4A P68366 2/20 0.76
▸ TUBB4B P68371 2/20 0.76
▸ TUBB3 Q13509 2/20 0.76
▸ TUBB2A Q13885 2/20 0.76
▸ TUBB8 Q3ZCM7 2/20 0.76
▸ TUBA3E Q6PEY2 2/20 0.76
▸ TUBA1A Q71U36 2/20 0.76
▸ TUBA1C Q9BQE3 2/20 0.76
▸ TUBB6 Q9BUF5 2/20 0.76

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nocodazole SCHEMBL9477 0.95 ABL1 (0.84) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL29360101 0.95 ABL1 (0.84) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL8009081 0.95 ABL1 (0.84) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL7615542 0.94 ABL1 (0.82) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL8198291 0.91 ABL1 (0.77) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL8195415 0.91 ABL1 (0.77) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL8186933 0.87 ABL1 (0.68) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL29573963 0.86 ABL1 (1.00) ABL1ALDH1A1LMNACYP1A2CYP2C9
Nocodazole SCHEMBL2324427 0.86 ABL1 (1.00) ABL1ALDH1A1LMNACYP1A2CYP2C9
SCHEMBL4204424 0.83 NPC1 (0.64) ABL1ALDH1A1LMNACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111658653-B Use of phosphodiesterase inhibitors 药捷安康(南京)科技股份有限公司 2022-09-09 — — CN disclosed
US-20220160696-A1 USES OF PHOSPHODIESTERASE INHIBITORS TRANSTHERA SCIENCES (NANJING), INC. (CN) 2022-05-26 — — US disclosed
EP-3939588-A1 USES OF PHOSPHODIESTERASE INHIBITORS Transthera Sciences (Nanjing), Inc. (CN) 2022-01-19 — — EP disclosed
WO-2020182076-A1 USES OF PHOSPHODIESTERASE INHIBITORS 南京药捷安康生物科技有限公司 2020-09-17 — — WO disclosed
CN-111658653-A Use of phosphodiesterase inhibitors 南京药捷安康生物科技有限公司 2020-09-15 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220160696-A1 USES OF PHOSPHODIESTERASE INHIBITORS PDE3A, PDE3B, PDE5A ABL1 2275/4885ALDH1A1 313/4885LMNA 2129/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.