Nocodazole

Nocodazole

SCHEMBL2324427

COC(=O)Nc1nc2ccc(C(=O)c3cccs3)cc2[nH]1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABL1 P00519 3/20 1.00
TUBB4A P04350 3/20 1.00
TUBB P07437 3/20 1.00
TUBA3C P0DPH7 3/20 1.00
TUBA1B P68363 3/20 1.00
TUBA4A P68366 3/20 1.00
TUBB4B P68371 3/20 1.00
TUBB3 Q13509 3/20 1.00
TUBB2A Q13885 3/20 1.00
TUBB8 Q3ZCM7 3/20 1.00
TUBA3E Q6PEY2 3/20 1.00
TUBA1A Q71U36 3/20 1.00
TUBA1C Q9BQE3 3/20 1.00
TUBB6 Q9BUF5 3/20 1.00
TUBB2B Q9BVA1 3/20 1.00
TUBB1 Q9H4B7 3/20 1.00
ALDH1A1 P00352 2/20 1.00
LMNA P02545 2/20 1.00
CYP1A2 P05177 2/20 1.00
CYP2C9 P11712 2/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Nocodazole SCHEMBL29573963 1.00 ABL1 (1.00) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL9477 0.91 ABL1 (0.84) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL8009081 0.91 ABL1 (0.84) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL29360101 0.91 ABL1 (0.84) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL7615542 0.90 ABL1 (0.82) ABL1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL24209744 0.89 ABL1 (0.81) ABL1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL4557188 0.87 ABL1 (0.78) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL8195415 0.87 ABL1 (0.77) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL8198291 0.87 ABL1 (0.77) ABL1TUBB4ATUBBTUBA3CTUBA1B
Nocodazole SCHEMBL22418403 0.86 ABL1 (0.76) ABL1TUBB4ATUBBTUBA3CTUBA1B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4720329-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SensID GmbH (DE) 2026-04-08 EP claimed
WO-2024246014-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SENSID GMBH (DE) 2024-12-05 WO claimed
EP-4467659-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS WITH A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSIS SensID GmbH (DE) 2024-11-27 EP claimed
EP-4720329-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SensID GmbH (DE) 2026-04-08 EP disclosed
WO-2024246014-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS HAVING A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSTIC METHOD SENSID GMBH (DE) 2024-12-05 WO disclosed
EP-4467659-A1 REFERENCE MATERIAL COMPRISING NUCLEIC ACIDS WITH A FRAGMENTATION AND NUCLEOSOME PROFILE AND DIAGNOSIS SensID GmbH (DE) 2024-11-27 EP disclosed
US-20230263783-A1 CANCER TREATMENT BY COMBINED INHIBITION OF POLO-LIKE KINASE AND MICROTUBULE POLYMERIZATION MASSACHUSETTS INSTITUTE OF TECHNOLOGY 2023-08-24 US disclosed
US-20230241034-A1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME UNIV MARYLAND (US) 2023-08-03 US disclosed
US-20220380367-A1 MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS THE UNIVERSITY OF MONTANA 2022-12-01 US disclosed
US-11420967-B2 Modified carbazoles as therapeutic agents UNIVERSITY OF WASHINGTON (US) 2022-08-23 US disclosed
US-20220017471-A1 FUNCTIONALITY INDEPENDENT LABELING OF ORGANIC COMPOUNDS UNIV SHANGHAI TECHNOLOGY (CN) 2022-01-20 US disclosed
US-6344207-B1 CLOTHING TORAY INDUSTRIES, INC. (JP) 2002-02-05 US disclosed
EP-1045065-A1 Cellulose fiber-containing structure TORAY INDUSTRIES, INC. (JP) 2000-10-18 EP disclosed
US-5985795-A CONTAINS INORGANIC METAL ANTIMICROBIAL AGENT, THIAZOLE ANTIMICROBIAL AGENT, HALOALKYLTHIO ANTIMICROBIAL AGENT, IMIDAZOLE ANTIMICROBIAL AGENT, AND UREA ANTIMICROBIAL AGENT Suganuma, Akio (JP) 1999-11-16 US disclosed
EP-0952248-A2 A molded antimicrobial article and a process for its production TORAY INDUSTRIES, INC. (JP) 1999-10-27 EP disclosed
EP-0834253-A2 Antimicrobial composition Suganuma, Akio (JP) 1998-04-08 EP disclosed
EP-0024842-B1 METHYL (5-(2-THIENYLHYDROXYMETHYL)-1H-BENZIMIDAZOL-2-YL) CARBAMATE, PROCESS FOR ITS PREPARATION AND COMPOSITIONS CONTAINING IT SMITHKLINE BECKMAN CORPORATION (US) 1983-10-05 EP disclosed
US-4321393-A Method for preparing 2-cyanamidobenzimidazoles or 2-cyanamidobenzoxazoles SMITHKLINE CORPORATION (US) 1982-03-23 US disclosed
US-4285878-A N-Phenyl-N'-cyano-O-phenylisoureas SMITHKLINE CORPORATION (US) 1981-08-25 US disclosed
EP-0024842-A1 Methyl (5-(2-thienylhydroxymethyl)-1H-benzimidazol-2-yl) carbamate, process for its preparation and compositions containing it SMITHKLINE BECKMAN CORPORATION (US) 1981-03-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220380367-A1 MODIFIED CARBAZOLES AS THERAPEUTIC AGENTS TUBB3, TUBB1, TUBA1C ABL1 784/4885TUBB4A 20/4885TUBB 4/4885
US-20230263783-A1 CANCER TREATMENT BY COMBINED INHIBITION OF POLO-LIKE KINASE AND MICROTUBULE POLYMERIZATION PLK2, PLK4, PLK1 ABL1 1690/4885TUBB4A 11/4885TUBB 6/4885
US-20220017471-A1 FUNCTIONALITY INDEPENDENT LABELING OF ORGANIC COMPOUNDS PAICS, PFAS, OTC ABL1 841/4885TUBB4A 622/4885TUBB 651/4885
US-20230241034-A1 MICROTUBULE POLYMERIZATION INHIBITOR PRODRUGS AND METHODS OF USING THE SAME TUBA1C, TUBB3, TUBB ABL1 3163/4885TUBB4A 6/4885TUBB 3/4885
US-11420967-B2 Modified carbazoles as therapeutic agents TUBB3, TUBB1, TUBA1C ABL1 784/4885TUBB4A 20/4885TUBB 4/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.