Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR4 | P22455 | 3/20 | 0.80 |
| ▸ | CYP1A2 | P05177 | 15/20 | 0.59 |
| ▸ | USP2 | O75604 | 15/20 | 0.59 |
| ▸ | CASP7 | P55210 | 9/20 | 0.59 |
| ▸ | CASP1 | P29466 | 8/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.59 |
| ▸ | MEN1 | O00255 | 7/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.57 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 3/20 | 0.52 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16071795 | 0.89 | FGFR4 (1.00) | FGFR4CYP1A2USP2CASP7CASP1 | |
| SCHEMBL16134080 | 0.88 | FGFR4 (0.74) | FGFR4CYP1A2USP2CASP7CASP1 | |
| SCHEMBL15611171 | 0.77 | FGFR4 (0.59) | FGFR4CYP1A2USP2CASP7CASP1 | |
| SCHEMBL7689910 | 0.75 | USP2 (0.81) | CYP1A2USP2CASP7CASP1ALDH1A1 | |
| SCHEMBL15434011 | 0.75 | FGFR4 (1.00) | FGFR4 | |
| SCHEMBL15413109 | 0.74 | CYP1A2 (0.58) | FGFR4CYP1A2USP2CASP7CASP1 | |
| SCHEMBL20682249 | 0.72 | FGFR1 (0.54) | FGFR4ALDH1A1PTK2 | |
| SCHEMBL15434039 | 0.69 | FGFR4 (0.59) | FGFR4CYP1A2USP2CASP7CASP1 | |
| SCHEMBL23315002 | 0.69 | CYP1A2 (0.53) | FGFR4CYP1A2USP2CASP7CASP1 | |
| SCHEMBL5519282 | 0.69 | FGFR1 (0.66) | FGFR4CYP1A2USP2CASP7CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10774052-B2 | Heteroaryl compounds and uses thereof | CELGENE CAR LLC (BM) | 2020-09-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10774052-B2 | Heteroaryl compounds and uses thereof | ABCG2, CYP3A43, CYP3A5 | FGFR4 2623/4885CYP1A2 20/4885USP2 3403/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.