Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 19/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 14/20 | 0.53 |
| ▸ | USP2 | O75604 | 13/20 | 0.53 |
| ▸ | MEN1 | O00255 | 10/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.53 |
| ▸ | CASP1 | P29466 | 10/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 10/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 9/20 | 0.53 |
| ▸ | CASP7 | P55210 | 9/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.53 |
| ▸ | TP53 | P04637 | 3/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.49 |
| ▸ | GLA | P06280 | 3/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15413109 | 0.93 | CYP1A2 (0.58) | CYP1A2ALDH1A1USP2MEN1KMT2A | |
| SCHEMBL21266720 | 0.75 | CYP1A1 (0.37) | CYP1A2CYP3A4CYP2C9FGFR4CYP2D6 | |
| SCHEMBL7694822 | 0.74 | CYP1A2 (0.68) | CYP1A2ALDH1A1USP2MEN1KMT2A | |
| SCHEMBL15412846 | 0.74 | CYP1A2 (0.50) | CYP1A2ALDH1A1USP2MEN1KMT2A | |
| SCHEMBL20331733 | 0.73 | NPC1 (0.51) | CYP1A2ALDH1A1CYP3A4CYP2C9CYP2D6 | |
| SCHEMBL15434039 | 0.70 | FGFR4 (0.59) | CYP1A2ALDH1A1USP2MEN1KMT2A | |
| SCHEMBL24335187 | 0.69 | KDM4E (0.56) | ALDH1A1FGFR4 | |
| SCHEMBL22420120 | 0.69 | FGFR4 (0.80) | CYP1A2ALDH1A1USP2MEN1KMT2A | |
| SCHEMBL18612966 | 0.69 | CYP11B1 (0.49) | CYP1A2ALDH1A1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL28648564 | 0.68 | FGFR1 (0.53) | FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2872491-B1 | INHIBITORS OF THE FIBROBLAST GROWTH FACTOR RECEPTOR | BLUEPRINT MEDICINES CORP (US) | 2021-05-05 | — | — | EP | disclosed |