Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 13/20 | 0.46 |
| ▸ | TYK2 | P29597 | 1/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 2/20 | 0.34 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20688041 | 0.79 | IDH1 (0.50) | IDH1TYK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20697244 | 0.77 | IDH1 (0.54) | IDH1TYK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20697242 | 0.76 | IDH1 (0.58) | IDH1TYK2PIK3CDPIK3CAPIK3CB | |
| SCHEMBL20889875 | 0.75 | IDH1 (0.44) | IDH1TYK2PIM1MAP4K1 | |
| SCHEMBL20909898 | 0.72 | RECQL (0.50) | IDH1TYK2PIM1 | |
| SCHEMBL20689588 | 0.70 | TYK2 (0.45) | IDH1TYK2PIM1MAP4K1 | |
| SCHEMBL31262446 | 0.70 | TYK2 (0.45) | IDH1TYK2PIM1MAP4K1 | |
| SCHEMBL23967033 | 0.69 | HTR3E (0.45) | IDH1TYK2PIK3CAPIM1MAP4K1 | |
| SCHEMBL4780 | 0.69 | ALOX5 (0.46) | IDH1TYK2PIM1MAP4K1 | |
| SCHEMBL20890070 | 0.69 | IDH1 (0.48) | IDH1TYK2PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3377496-B1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL MYERS SQUIBB CO (US) | 2020-09-16 | — | — | EP | disclosed |