Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 6/20 | 0.42 |
| ▸ | RAB9A | P51151 | 5/20 | 0.42 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22425270 | 0.91 | POLB (0.53) | POLBNPC1RAB9ASMN1; SMN2GAA | |
| SCHEMBL22425266 | 0.87 | HSD17B10 (0.53) | NPC1RAB9ASMN1; SMN2PKMMEN1 | |
| SCHEMBL9969945 | 0.77 | TAAR1 (0.48) | POLBNPC1RAB9AGAAMEN1 | |
| SCHEMBL7525964 | 0.69 | TDP1 (0.52) | TDP1POLBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7789892 | 0.69 | POLB (0.42) | TDP1POLBGAAMEN1LMNA | |
| SCHEMBL16273924 | 0.69 | CYP3A4 (0.40) | POLBSMN1; SMN2MEN1HTTKMT2A | |
| Toluene SCHEMBL1159746 | 0.68 | L3MBTL1 (0.41) | TDP1POLBNPC1RAB9ASMN1; SMN2 | |
| Toluene SCHEMBL1079482 | 0.68 | L3MBTL1 (0.41) | TDP1POLBNPC1RAB9ASMN1; SMN2 | |
| Toluene SCHEMBL8907280 | 0.68 | L3MBTL1 (0.41) | TDP1POLBNPC1RAB9ASMN1; SMN2 | |
| Toluene SCHEMBL8994440 | 0.68 | L3MBTL1 (0.41) | TDP1POLBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020186202-A1 | SMALL MOLECULE GRB2 STABILIZERS FOR RAS MAP KINASE INHIBITION | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2020-09-17 | — | — | WO | disclosed |