SCHEMBL224279

SCHEMBL224279

NC(=O)Nc1ccc(Cl)cc1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 5/20 1.00
PEPD P12955 1/20 0.64
ALDH1A1 P00352 6/20 0.61
MAPT P10636 5/20 0.60
HTT P42858 4/20 0.60
GAA P10253 3/20 0.57
GFER P55789 1/20 0.57
TSHR P16473 2/20 0.56
HPGD P15428 1/20 0.56
ALOX15 P16050 1/20 0.56
HSD17B10 Q99714 1/20 0.56
MEN1 O00255 5/20 0.55
KMT2A Q03164 5/20 0.55
KIF11 P52732 2/20 0.55
LMNA P02545 2/20 0.55
CA12 O43570 1/20 0.53
CA1 P00915 1/20 0.53
CA2 P00918 1/20 0.53
CA9 Q16790 1/20 0.53
KDM4E B2RXH2 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Propyne SCHEMBL28961099 0.88 NPC1 (0.78) NPC1PEPDALDH1A1MAPTHTT
SCHEMBL4092732 0.88 NPC1 (0.78) NPC1PEPDALDH1A1MAPTHTT
SCHEMBL5062623 0.87 PEPD (0.80) NPC1PEPDALDH1A1MAPTGAA
Phenylurea SCHEMBL28801186 0.85 NPC1 (0.73) NPC1PEPDALDH1A1MAPTHTT
SCHEMBL28597947 0.83 NPC1 (0.70) NPC1ALDH1A1MAPTHTTGAA
SCHEMBL672629 0.82 NPC1 (0.69) NPC1ALDH1A1MAPTHTTGAA
SCHEMBL11048619 0.80 MEN1 (0.76) NPC1ALDH1A1MAPTHTTTSHR
SCHEMBL4741253 0.80 MEN1 (0.76) NPC1ALDH1A1MAPTHTTTSHR
SCHEMBL21568080 0.80 NPC1 (0.67) NPC1ALDH1A1MAPTHTTGAA
SCHEMBL29484170 0.80 EPHX1 (0.69) NPC1ALDH1A1MAPTHTTGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 877 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118685634-A Separation and recovery method for lithium ions in retired waste lithium batteries based on nanofiltration-reverse osmosis method 广东奥斯博膜材料技术有限公司 2024-09-24 CN claimed
CN-115850123-B Preparation method of 2, 4-dichloroaniline/hydrazine 山东潍坊润丰化工股份有限公司 2024-04-19 CN claimed
CN-113831301-B Benzothiazole derivative and application thereof 沈阳药科大学 2023-06-06 CN claimed
WO-2023092727-A1 X-RAY DIRECT DETECTOR AND METHOD FOR PREPARING SAME 中国科学院深圳先进技术研究院 2023-06-01 WO claimed
CN-115850123-A Preparation method of 2, 4-dichloroaniline/hydrazine 山东潍坊润丰化工股份有限公司 2023-03-28 CN claimed
CN-115532081-A Acid-resistant positive charge nanofiltration composite membrane and preparation method thereof 广东奥斯博膜材料技术有限公司 2022-12-30 CN claimed
CN-115515944-A Benzothiazole derivative and application thereof 沈阳药科大学 2022-12-23 CN claimed
CN-217961385-U Device for selectively removing impurities in a cleaning fluid 开尔弗森2200有限公司 2022-12-06 CN claimed
CN-115000310-A Perovskite coating, preparation method thereof and X-ray detector 中国科学院深圳先进技术研究院 2022-09-02 CN claimed
CN-114361203-A X-ray direct detector and preparation method thereof 中国科学院深圳先进技术研究院 2022-04-15 CN claimed
EP-0929553-A1 PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF Novartis AG (CH) 1999-07-21 EP claimed
CN-1221316-A Benzoylurea insecticides on gene-modified Bt cotton UNIROYAL CHEM CO INC (US) 1999-06-30 CN claimed
WO-1998014450-A1 PYRIMIDINE DERIVATIVES AND PROCESSES FOR THE PREPARATION THEREOF NOVARTIS AG (CH) 1998-04-09 WO claimed
US-5696110-A ANTIULCER AGENTS MERCK, SHARP & DOHME, LTD. (GB) 1997-12-09 US claimed
CN-1138853-A 1,5-benzodiazepine derivatives useful as CCK or gastrin antagonists GLAXO SPA (IT) 1996-12-25 CN claimed
US-5290947-A Process for the preparation of pyrrole derivates CASSELLA AKTIENGESELLSCHAFT (DE) 1994-03-01 US claimed
EP-0564841-A1 Process for the preparation of pyrrole derivatives CASSELLA Aktiengesellschaft (DE) 1993-10-13 EP claimed
EP-0213326-B1 2,5-DIMETHYL PYRROLE DERIVATIVES, THEIR PREPARATION AND THEIR USE CASSELLA Aktiengesellschaft (DE) 1991-03-06 EP claimed
EP-0323077-A1 Heterocyclic compounds JOHN WYETH & BROTHER LIMITED (GB) 1989-07-05 EP claimed
US-4250319-A RIPENER FOR SUGARCANE W. R. GRACE & CO. (US) 1981-02-10 US claimed