Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | CDK9 | P50750 | 2/20 | 0.56 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.56 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 5/20 | 0.55 |
| ▸ | STK3 | Q13188 | 4/20 | 0.55 |
| ▸ | DYRK1B | Q9Y463 | 2/20 | 0.55 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.55 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20744209 | 0.78 | ROCK2 (0.60) | EGFRCDK2CDK9CDK5CCNT1 | |
| SCHEMBL30668720 | 0.78 | ROCK2 (0.60) | EGFRCDK2CDK9CDK5CCNT1 | |
| SCHEMBL857887 | 0.75 | CDC7 (0.69) | CDK2CDK9CDK5CCNT1CCNA2 | |
| SCHEMBL24672968 | 0.75 | ROCK1 (0.58) | CDK2CDK9CDK5CCNT1CCNA2 | |
| SCHEMBL857272 | 0.75 | LRRK2 (0.43) | EGFRCDK2CDK9CDK5LRRK2 | |
| SCHEMBL24672397 | 0.74 | CDK9 (0.57) | EGFRCDK2CDK9CDK5CCNT1 | |
| SCHEMBL24672937 | 0.74 | ROCK1 (0.57) | EGFRCDK2CDK9CDK5CCNT1 | |
| SCHEMBL857026 | 0.73 | LRRK2 (0.46) | EGFRCDK2CDK9CDK5LRRK2 | |
| SCHEMBL20744032 | 0.72 | ROCK2 (0.60) | EGFRCDK2CDK9CDK5CCNT1 | |
| SCHEMBL30668710 | 0.72 | ROCK2 (0.60) | EGFRCDK2CDK9CDK5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| US-20110201599-A1 | CDK Modulators | EXELIXIS, INC. (US) | 2011-08-18 | — | — | US | disclosed |
| WO-2010003133-A2 | CDK MODULATORS | EXELIXIS INC. (US) | 2010-01-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201599-A1 | CDK Modulators | CDK3, CDK1, CDKL1 | EGFR 1213/4885CDK2 7/4885CDK9 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.