Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 4/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HBB | P68871 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30679119 | 1.00 | ALDH1A1 (0.40) | ALDH1A1KDM4ELMNAUSP2KMT2A | |
| SCHEMBL30679099 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KDM4ELMNAUSP2KMT2A | |
| SCHEMBL22436698 | 0.84 | ALDH1A1 (0.39) | ALDH1A1KDM4ELMNAUSP2KMT2A | |
| SCHEMBL22436668 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNAUSP2PIM1 | |
| SCHEMBL30679120 | 0.78 | ALDH1A1 (0.38) | ALDH1A1KDM4ELMNAUSP2PIM1 | |
| SCHEMBL23844483 | 0.77 | KDM4E (0.36) | ALDH1A1KDM4ELMNAPIM1 | |
| SCHEMBL22436737 | 0.76 | CSNK2A1 (0.35) | ALDH1A1 | |
| SCHEMBL30679095 | 0.76 | CSNK2A1 (0.35) | ALDH1A1 | |
| SCHEMBL22436703 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KDM4EUSP2MAPK1TSHR | |
| SCHEMBL22436705 | 0.74 | ALDH1A1 (0.39) | ALDH1A1KDM4EUSP2MAPK1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710456-B1 | MACROCYCLIC INDOLE DERIVATIVES | BROAD INST INC (US) | 2022-09-21 | — | — | EP | disclosed |
| US-11440923-B2 | Substituted macrocyclic indole derivatives | BAYER PHARMA AKTIENGESELLSCHAFT (DE) | 2022-09-13 | — | — | US | disclosed |
| US-11401278-B2 | Macrocyclic indole derivatives | THE BROAD INSTITUTE, INC. (US) | 2022-08-02 | — | — | US | disclosed |
| US-20210292341-A1 | MACROCYCLIC INDOLE DERIVATIVES | BAYER AKTIENGESELLSCHAFT (DE) | 2021-09-23 | — | — | US | disclosed |
| EP-3710456-A1 | MACROCYCLIC INDOLE DERIVATIVES | The Broad Institute, Inc. (US) | 2020-09-23 | — | — | EP | disclosed |
| EP-3710451-A1 | SUBSTITUTED MACROCYCLIC INDOLE DERIVATIVES | Bayer Aktiengesellschaft (DE) | 2020-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210292341-A1 | MACROCYCLIC INDOLE DERIVATIVES | CCND2, CCNA1, CCNT2 | ALDH1A1 1379/4885KDM4E 2044/4885LMNA 933/4885 |
| US-11401278-B2 | Macrocyclic indole derivatives | CCND2, CCNA1, CCNT2 | ALDH1A1 1379/4885KDM4E 2044/4885LMNA 933/4885 |
| US-11440923-B2 | Substituted macrocyclic indole derivatives | FOXM1, CCND2, CCNI | ALDH1A1 1000/4885KDM4E 1649/4885LMNA 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.