Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATF4 | P18848 | 11/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | SENP2 | Q9HC62 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19556219 | 1.00 | ATF4 (0.37) | ATF4ALDH1A1GAASENP2HDAC6 | |
| SCHEMBL32689691 | 0.94 | SENP2 (0.44) | ATF4ALDH1A1GAASENP2TSHR | |
| SCHEMBL22628079 | 0.94 | SENP2 (0.44) | ATF4ALDH1A1GAASENP2TSHR | |
| SCHEMBL22956629 | 0.94 | ATF4 (0.38) | ATF4ALDH1A1HPGDTSHRMAPT | |
| SCHEMBL19556229 | 0.94 | ATF4 (0.45) | ATF4 | |
| SCHEMBL19555951 | 0.94 | ATF4 (0.45) | ATF4 | |
| SCHEMBL22612518 | 0.93 | KCNH2 (0.40) | ATF4ALDH1A1GAASENP2HDAC6 | |
| SCHEMBL22437133 | 0.93 | KCNH2 (0.40) | ATF4ALDH1A1GAASENP2HDAC6 | |
| SCHEMBL22628519 | 0.92 | ATF4 (0.47) | ATF4SENP2TSHRMAPT | |
| SCHEMBL22628052 | 0.91 | USP2 (0.36) | ATF4SENP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-23 | — | — | EP | disclosed |