Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ATF4 | P18848 | 11/20 | 0.37 |
| ▸ | GBA1 | P04062 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22612566 | 1.00 | ALDH1A1 (0.38) | ALDH1A1GAAATF4GBA1BACE1 | |
| SCHEMBL19556068 | 0.94 | ATF4 (0.45) | ATF4 | |
| SCHEMBL22437149 | 0.91 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19555937 | 0.91 | ATF4 (0.46) | ATF4 | |
| SCHEMBL22628282 | 0.84 | ATF4 (0.47) | ATF4 | |
| SCHEMBL19555948 | 0.83 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19555935 | 0.83 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19555859 | 0.83 | ATF4 (0.46) | ATF4 | |
| SCHEMBL19556219 | 0.83 | ATF4 (0.37) | ALDH1A1GAAATF4 | |
| SCHEMBL22436967 | 0.83 | ATF4 (0.39) | ALDH1A1GAAATF4GBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-23 | — | — | EP | disclosed |