Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.42 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | FAAH | O00519 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19556316 | 1.00 | NLRP3 (0.42) | NLRP3HDAC4HDAC6NPC1RAB9A | |
| SCHEMBL21678923 | 0.86 | NLRP3 (0.40) | NLRP3HDAC4HDAC6NPC1RAB9A | |
| SCHEMBL21679172 | 0.82 | NLRP3 (0.40) | NLRP3HDAC4HDAC6NPC1RAB9A | |
| SCHEMBL21679454 | 0.79 | FAAH (0.41) | NPC1RAB9AL3MBTL1ALDH1A1FAAH | |
| SCHEMBL19556453 | 0.78 | NLRP3 (0.43) | NLRP3HDAC4HDAC6NPC1RAB9A | |
| SCHEMBL19556007 | 0.75 | NLRP3 (0.41) | NLRP3HDAC4HDAC6NPC1RAB9A | |
| SCHEMBL19556078 | 0.74 | NLRP3 (0.40) | NLRP3HDAC4HDAC6MAPTPDE10A | |
| SCHEMBL15495219 | 0.72 | TSHR (0.39) | RAB9AALDH1A1KMT2AGAAKDM4E | |
| SCHEMBL31706099 | 0.72 | NLRP3 (0.39) | NLRP3HDAC4HDAC6NPC1RAB9A | |
| SCHEMBL19556335 | 0.71 | HDAC4 (0.43) | NLRP3HDAC4HDAC6NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3710428-A1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | Calico Life Sciences LLC (US) | 2020-09-23 | — | — | EP | disclosed |