Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 14/20 | 0.68 |
| ▸ | HDAC8 | Q9BY41 | 12/20 | 0.68 |
| ▸ | HDAC3 | O15379 | 11/20 | 0.68 |
| ▸ | HDAC2 | Q92769 | 11/20 | 0.68 |
| ▸ | NCOR2 | Q9Y618 | 3/20 | 0.68 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 7/20 | 0.62 |
| ▸ | HDAC7 | Q8WUI4 | 7/20 | 0.62 |
| ▸ | HDAC11 | Q96DB2 | 7/20 | 0.62 |
| ▸ | HDAC9 | Q9UKV0 | 7/20 | 0.62 |
| ▸ | HDAC5 | Q9UQL6 | 7/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 6/20 | 0.62 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.62 |
| ▸ | BRD4 | O60885 | 1/20 | 0.62 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.62 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | LTA4H | P09960 | 1/20 | 0.62 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20952239 | 0.86 | HDAC1 (0.91) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL22439787 | 0.85 | ICMT (0.65) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL22439796 | 0.84 | ICMT (0.71) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL22439785 | 0.84 | ICMT (0.76) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL22483752 | 0.83 | HDAC1 (0.76) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL19478284 | 0.83 | HDAC1 (0.79) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL13965309 | 0.80 | HDAC1 (1.00) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL23055007 | 0.80 | HDAC1 (0.96) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL12659217 | 0.80 | HDAC1 (0.89) | HDAC1HDAC8HDAC3HDAC2NCOR2 | |
| SCHEMBL22439778 | 0.80 | HDAC1 (0.68) | HDAC1HDAC8HDAC3HDAC2NCOR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2022-05-19 | — | — | US | disclosed |
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2022-05-19 | — | — | US | disclosed |
| EP-3941900-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | Deutsches Krebsforschungszentrum (DE) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020193431-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2020-10-01 | — | — | WO | disclosed |
| WO-2020193431-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | DEUTSCHES KREBSFORSCHUNGSZENTRUM (DE) | 2020-10-01 | — | — | WO | disclosed |
| EP-3712127-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | Deutsches Krebsforschungszentrum (DE) | 2020-09-23 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220151962-A1 | NOVEL INHIBITORS OF HISTONE DEACETYLASE 10 | HDAC10, HDAC1, HDAC11 | HDAC1 2/4885HDAC8 8/4885HDAC3 11/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.