SCHEMBL22441574

SCHEMBL22441574

COc1cc2nccc(N3CCC(C(=O)O)CC3)c2cc1OC

nearest known ligand 0.63

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
EHMT2 Q96KQ7 4/20 0.63
EHMT1 Q9H9B1 4/20 0.63
NCF1 P14598 1/20 0.62
PDGFRB P09619 1/20 0.55
MAPK1 P28482 1/20 0.49
KMT2A Q03164 4/20 0.47
NEK2 P51955 1/20 0.47
EGFR P00533 1/20 0.46
ALDH1A1 P00352 2/20 0.46
NPC1 O15118 1/20 0.46
MEN1 O00255 1/20 0.45
KDM4E B2RXH2 1/20 0.45
ENPP1 P22413 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29357438 0.89 EHMT2 (0.63) EHMT2EHMT1NCF1PDGFRBMAPK1
SCHEMBL22441527 0.85 MAPK1 (0.69) EHMT2EHMT1NCF1PDGFRBMAPK1
SCHEMBL22445606 0.84 NCF1 (0.70) EHMT2EHMT1NCF1PDGFRBEGFR
SCHEMBL22441471 0.83 NCF1 (0.59) EHMT2EHMT1NCF1PDGFRBMAPK1
SCHEMBL29357443 0.83 NCF1 (0.68) EHMT2EHMT1NCF1PDGFRBNPC1
SCHEMBL22455396 0.83 NCF1 (0.68) EHMT2EHMT1NCF1PDGFRBNPC1
SCHEMBL22291005 0.82 NCF1 (0.67) EHMT2EHMT1NCF1PDGFRBNPC1
Hydrochloric Acid SCHEMBL22441576 0.81 NCF1 (0.67) EHMT2EHMT1NCF1PDGFRBNPC1
Hydrochloric Acid SCHEMBL22441583 0.81 NCF1 (0.67) EHMT2EHMT1NCF1PDGFRBNPC1
SCHEMBL22441522 0.81 NCF1 (0.65) EHMT2EHMT1NCF1PDGFRBNPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3941459-B1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF STINGRAY THERAPEUTICS INC (US) 2026-05-06 EP disclosed
CN-113924092-B Quinoline and quinazoline compounds and methods of use thereof 斯汀格瑞治疗股份有限公司 2025-03-18 CN disclosed
US-11407729-B2 Quinoline and quinazoline compounds and methods of use thereof Stingray Therapeutics, Inc. (US) 2022-08-09 US disclosed
US-11407729-B2 Quinoline and quinazoline compounds and methods of use thereof Stingray Therapeutics, Inc. (US) 2022-08-09 US disclosed
EP-3941459-A1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF Stingray Therapeutics, Inc. (US) 2022-01-26 EP disclosed
CN-113924092-A Quinoline and quinazoline compounds and methods of use thereof 斯汀格瑞治疗股份有限公司 2022-01-11 CN disclosed
US-20200299258-A1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF STINGRAY THERAPEUTICS INC (US) 2020-09-24 US disclosed
US-20200299258-A1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF STINGRAY THERAPEUTICS INC (US) 2020-09-24 US disclosed
WO-2020190912-A1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF Stingray Therapeutics, Inc. (US) 2020-09-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200299258-A1 QUINOLINE AND QUINAZOLINE COMPOUNDS AND METHODS OF USE THEREOF ENPP1, ENPP3, PDE7A EHMT2 2342/4885EHMT1 1468/4885NCF1 283/4885
US-11407729-B2 Quinoline and quinazoline compounds and methods of use thereof ENPP1, ENPP3, PDE7A EHMT2 2342/4885EHMT1 1468/4885NCF1 283/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.