Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 7/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.54 |
| ▸ | PKM | P14618 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.52 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.52 |
| ▸ | MPO | P05164 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29454821 | 0.88 | HTR2A (0.66) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL678456 | 0.88 | HTR2A (0.66) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2241359 | 0.87 | HTR2A (0.57) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2242091 | 0.86 | HTR2A (0.60) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2243980 | 0.85 | KMT2A (0.62) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6408868 | 0.84 | HTR2A (0.61) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2243718 | 0.80 | HTR2A (0.65) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2243480 | 0.77 | CDK2 (0.73) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL11956684 | 0.77 | KMT2A (0.62) | HTR2AMEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL2246486 | 0.77 | HTR2A (0.62) | HTR2AMEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528689-B | Substituted aryl indole compounds and their kynurenine/kynuramine metabolites as therapeutic agents | NEURIM PHARMA 1991 | 2013-04-24 | — | — | CN | claimed |
| US-20100048663-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2010-02-25 | — | — | US | claimed |
| US-7622495-B2 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2009-11-24 | — | — | US | claimed |
| EP-2086932-B1 | SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS | NEURIM PHARMA 1991 (IL) | 2014-08-27 | — | — | EP | disclosed |
| EP-2086932-B1 | SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS | NEURIM PHARMA 1991 (IL) | 2014-08-27 | — | — | EP | disclosed |
| EP-2664615-A1 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LIMITED (IL) | 2013-11-20 | — | — | EP | disclosed |
| CN-101528689-B | Substituted aryl indole compounds and their kynurenine/kynuramine metabolites as therapeutic agents | NEURIM PHARMA 1991 | 2013-04-24 | — | — | CN | disclosed |
| US-8236858-B2 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2012-08-07 | — | — | US | disclosed |
| US-8236858-B2 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2012-08-07 | — | — | US | disclosed |
| US-8236858-B2 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2012-08-07 | — | — | US | disclosed |
| US-20110319494-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2011-12-29 | — | — | US | disclosed |
| US-7622495-B2 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2009-11-24 | — | — | US | disclosed |
| US-7622495-B2 | Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2009-11-24 | — | — | US | disclosed |
| CN-101528689-A | Substituted aryl indole compounds and their kynurenine/kynuramine metabolites as therapeutic agents | NEURIM PHARMA 1991 (IL) | 2009-09-09 | — | — | CN | disclosed |
| EP-2086932-A2 | SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS | NEURIM PHARMACEUTICALS (1991) LIMITED (IL) | 2009-08-12 | — | — | EP | disclosed |
| US-20080132559-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2008-06-05 | — | — | US | disclosed |
| US-20080132559-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2008-06-05 | — | — | US | disclosed |
| US-20080132559-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | NEURIM PHARMACEUTICALS (1991) LTD. (IL) | 2008-06-05 | — | — | US | disclosed |
| WO-2008041140-A2 | SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS | NEURIM PHARMACEUTICALS (1991) LTD. (US) | 2008-04-10 | — | — | WO | disclosed |
| WO-2008041140-A2 | SUBSTITUTED ARYL-INDOLE COMPOUNDS AND THEIR KYNURENINE/KYNURAMINE-LIKE METABOLITES AS THERAPEUTIC AGENTS | NEURIM PHARMACEUTICALS (1991) LTD. (US) | 2008-04-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132559-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | KYNU, KMO, GRIN1 | HTR2A 70/4885MEN1 4127/4885KMT2A 112/4885 |
| US-20100048663-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | KYNU, KMO, GRIN1 | HTR2A 70/4885MEN1 4127/4885KMT2A 112/4885 |
| US-20110319494-A1 | Substituted Aryl-Indole Compounds and Their Kynurenine/Kynuramine-Like Metabolites As Therapeutic Agents | KYNU, KMO, GRIN1 | HTR2A 70/4885MEN1 4127/4885KMT2A 112/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.