Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 19/20 | 0.60 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24433243 | 0.91 | TRPC5 (0.69) | TRPC5TRPC4KCNH2P2RX7 | |
| SCHEMBL22445533 | 0.82 | TRPC5 (0.83) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831205 | 0.81 | TRPC5 (0.53) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831554 | 0.80 | TRPC5 (0.68) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831958 | 0.80 | TRPC5 (0.68) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831957 | 0.80 | TRPC5 (0.68) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20818307 | 0.79 | TRPC5 (0.55) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20818309 | 0.79 | TRPC5 (0.55) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20818555 | 0.79 | TRPC5 (0.55) | TRPC5TRPC4KCNH2 | |
| SCHEMBL31574303 | 0.79 | TRPC5 (0.55) | TRPC5TRPC4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3941475-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | Goldfinch Bio, Inc. (US) | 2022-01-26 | — | — | EP | disclosed |
| WO-2020191056-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. (US) | 2020-09-24 | — | — | WO | disclosed |