Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC5 | Q9UL62 | 19/20 | 0.69 |
| ▸ | TRPC4 | Q9UBN4 | 2/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.53 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22445571 | 0.91 | TRPC5 (0.60) | TRPC5TRPC4KCNH2P2RX7 | |
| SCHEMBL20831958 | 0.88 | TRPC5 (0.68) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831205 | 0.88 | TRPC5 (0.53) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831957 | 0.88 | TRPC5 (0.68) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831554 | 0.88 | TRPC5 (0.68) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20831451 | 0.82 | TRPC5 (1.00) | TRPC5TRPC4KCNH2 | |
| SCHEMBL20818056 | 0.81 | TRPC5 (0.69) | TRPC5TRPC4KCNH2P2RX7 | |
| SCHEMBL20831288 | 0.81 | TRPC5 (0.69) | TRPC5TRPC4KCNH2P2RX7 | |
| SCHEMBL20818071 | 0.81 | TRPC5 (0.69) | TRPC5TRPC4KCNH2P2RX7 | |
| SCHEMBL25708988 | 0.80 | TRPC5 (0.55) | TRPC5TRPC4KCNH2P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GFB (ABC), LLC | 2023-06-29 | — | — | US | disclosed |
| US-20220152031-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GOLDFINCH BIO, INC. | 2022-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230203028-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | PDXK, ATP6V1B1, REN | TRPC5 1439/4885TRPC4 2143/4885KCNH2 915/4885 |
| US-20220152031-A1 | PYRIDAZINONES AND METHODS OF USE THEREOF | GLS, ATP6V1B1, PDXK | TRPC5 3626/4885TRPC4 4095/4885KCNH2 966/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.