Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NNMT | P40261 | 2/20 | 0.42 |
| ▸ | HMGCR | P04035 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.37 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | ERN1 | O75460 | 1/20 | 0.36 |
| ▸ | NOS3 | P29474 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.36 |
| ▸ | NOS2 | P35228 | 1/20 | 0.36 |
| ▸ | DAO | P14920 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31434961 | 0.83 | PRKCE (0.43) | NNMTHMGCRRAB9ASIRT6MEN1 | |
| SCHEMBL18314758 | 0.81 | NNMT (0.39) | NNMTRAB9ASIRT6MEN1KMT2A | |
| SCHEMBL27752629 | 0.78 | TAAR1 (0.44) | NNMTRAB9AGAANOS3NOS1 | |
| SCHEMBL10263430 | 0.78 | NOS3 (0.55) | NNMTRAB9ASIRT6MEN1KMT2A | |
| SCHEMBL24456147 | 0.78 | NNMT (0.40) | NNMTRAB9ASIRT6MEN1KMT2A | |
| SCHEMBL15941382 | 0.77 | NOS3 (0.44) | NNMTRAB9ASIRT6NOS3NOS1 | |
| SCHEMBL16800619 | 0.77 | NNMT (0.39) | NNMTRAB9ASIRT6MEN1KMT2A | |
| SCHEMBL8232977 | 0.77 | NNMT (0.46) | NNMTRAB9ASIRT6MEN1KMT2A | |
| SCHEMBL23723761 | 0.76 | ERN1 (0.41) | NNMTSIRT6MEN1KMT2APABPC1 | |
| SCHEMBL16201837 | 0.75 | NOS3 (0.41) | MEN1KMT2AGAAPABPC1NOS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3712144-A1 | P2X3 AND/OR P2X2/3 RECEPTOR ANTAGONIST, PHARMACEUTICAL COMPOSITION COMPRISING SAME, AND USE THEREOF | Beijing Tide Pharmaceutical Co., Ltd. (CN) | 2020-09-23 | — | — | EP | disclosed |