Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 12/20 | 0.64 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | XBP1 | P17861 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 1/20 | 0.51 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15096517 | 1.00 | TPH1 (0.64) | TPH1SMPD1MAPTHTTSMN1; SMN2 | |
| SCHEMBL15037368 | 0.97 | TPH1 (0.59) | TPH1SMPD1MAPTHTTSMN1; SMN2 | |
| SCHEMBL15037265 | 0.93 | TPH1 (0.54) | TPH1SMPD1MAPTHTTSMN1; SMN2 | |
| SCHEMBL15096518 | 0.92 | TPH1 (0.53) | TPH1SMPD1MAPTSMN1; SMN2LMNA | |
| SCHEMBL15037278 | 0.92 | TPH1 (0.53) | TPH1SMPD1MAPTSMN1; SMN2LMNA | |
| SCHEMBL22449247 | 0.89 | S1PR4 (0.54) | TPH1MAPTHTTSMN1; SMN2LMNA | |
| SCHEMBL15037155 | 0.89 | S1PR4 (0.54) | TPH1MAPTHTTSMN1; SMN2LMNA | |
| SCHEMBL15037267 | 0.89 | TPH1 (0.52) | TPH1SMPD1MAPTSMN1; SMN2KDM4E | |
| SCHEMBL15037262 | 0.88 | TPH1 (0.61) | TPH1MAPTL3MBTL1KDM4EMEN1 | |
| SCHEMBL15037361 | 0.87 | TPH1 (0.53) | TPH1SMPD1MAPTSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |