Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 7/20 | 0.51 |
| ▸ | PPARA | Q07869 | 6/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.51 |
| ▸ | S1PR1 | P21453 | 3/20 | 0.49 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.49 |
| ▸ | TPH1 | P17752 | 2/20 | 0.48 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.47 |
| ▸ | ITGB3 | P05106 | 2/20 | 0.47 |
| ▸ | ITGAV | P06756 | 1/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.47 |
| ▸ | ITGA4 | P13612 | 2/20 | 0.47 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.46 |
| ▸ | ACACB | O00763 | 1/20 | 0.46 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15037257 | 1.00 | PPARG (0.51) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15019772 | 0.94 | ITGB1 (0.53) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15037102 | 0.94 | ITGB1 (0.53) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15037029 | 0.94 | ITGB1 (0.53) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15091874 | 0.94 | ITGB1 (0.53) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15037155 | 0.90 | S1PR4 (0.54) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL22449247 | 0.90 | S1PR4 (0.54) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15037260 | 0.89 | GPR132 (0.55) | PPARGPPARAPPARDGPR132 | |
| SCHEMBL15037113 | 0.89 | TPH1 (0.51) | PPARGPPARAPPARDS1PR1S1PR3 | |
| SCHEMBL15037262 | 0.89 | TPH1 (0.61) | PPARGPPARAPPARDS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |