Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 11/20 | 0.57 |
| ▸ | PPARG | P37231 | 3/20 | 0.49 |
| ▸ | PPARD | Q03181 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 2/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 4/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 2/20 | 0.44 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22449147 | 0.86 | S1PR1 (0.59) | TPH1PPARGPPARDPPARAS1PR1 | |
| SCHEMBL22448969 | 0.86 | TPH1 (0.58) | TPH1PPARGPPARDPPARAS1PR1 | |
| SCHEMBL22449171 | 0.86 | TPH1 (0.56) | TPH1PPARGS1PR1NR1H4S1PR4 | |
| SCHEMBL15037113 | 0.86 | TPH1 (0.51) | TPH1PPARGPPARDPPARAS1PR1 | |
| SCHEMBL22449162 | 0.85 | NPC1 (0.57) | TPH1PPARGPPARDPPARAS1PR1 | |
| SCHEMBL22449244 | 0.84 | PPARG (0.57) | TPH1PPARGPPARDPPARA | |
| SCHEMBL22449105 | 0.84 | TPH1 (0.57) | TPH1PPARGS1PR1S1PR4S1PR5 | |
| SCHEMBL22449070 | 0.83 | TPH1 (0.54) | TPH1PPARGPPARDPPARAS1PR1 | |
| SCHEMBL13660693 | 0.83 | ACACB (0.50) | PPARGPPARAKMT2A | |
| SCHEMBL2034306 | 0.83 | ACACB (0.50) | PPARGPPARAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2791112-B1 | CARBOXYLIC ACID DERIVATIVES COMPRISING FOUR CYCLES ACTING AS GLP-1 RECEPTOR MODULATORS FOR THERAPY OF DISEASES SUCH AS DIABETES | CELGENE INT II SÀRL (CH) | 2020-09-23 | — | — | EP | disclosed |