SCHEMBL22449433

SCHEMBL22449433

Oc1ccc(-c2nc3ccccc3c3cc4ccccn4c23)cc1

nearest known ligand 0.49

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.49
▸ KMT2A Q03164 1/20 0.49
▸ RAD51 Q06609 4/20 0.45
▸ DHODH Q02127 3/20 0.45
▸ USP7 Q93009 4/20 0.41
▸ POLB P06746 1/20 0.40
▸ TNKS O95271 1/20 0.38
▸ GUSB P08236 1/20 0.38
▸ PARP1 P09874 1/20 0.38
▸ TNKS2 Q9H2K2 1/20 0.38
▸ TNK2 Q07912 1/20 0.37
▸ PDE10A Q9Y233 1/20 0.37
▸ ESR1 P03372 1/20 0.36
▸ ALDH1A1 P00352 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17620557 0.90 KDM4E (0.40) RAD51DHODHPDE10AALDH1A1
SCHEMBL17620587 0.87 KDM4E (0.49) MEN1KMT2APOLBTNKSGUSB
SCHEMBL22449438 0.87 RAD51 (0.50) MEN1KMT2ARAD51TNKSPARP1
SCHEMBL17620591 0.87 NPC1 (0.44) RAD51TNKSTNKS2ALDH1A1
SCHEMBL17620569 0.87 CYP19A1 (0.47) MEN1KMT2ARAD51TNKSTNKS2
SCHEMBL17620578 0.87 TDP1 (0.49) POLBTNKSPARP1TNKS2ALDH1A1
SCHEMBL21656455 0.87 RAD51 (0.38) MEN1KMT2ARAD51DHODHALDH1A1
SCHEMBL17620562 0.84 RAB9A (0.40) RAD51DHODHPOLBESR1ALDH1A1
SCHEMBL18396441 0.84 RAD51 (0.53) MEN1KMT2ARAD51GUSBTNK2
SCHEMBL17620548 0.84 KDM4E (0.52) MEN1KMT2AUSP7POLBALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10787448-B2 Indolizino [3,2-C] quinoline-based fluorescent probe SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) 2020-09-29 — — US claimed
US-10787448-B2 Indolizino [3,2-C] quinoline-based fluorescent probe SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) 2020-09-29 — — US disclosed
US-10787448-B2 Indolizino [3,2-C] quinoline-based fluorescent probe SEOUL NATIONAL UNIVERSITY R & DB FOUNDATION (KR) 2020-09-29 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10787448-B2 Indolizino [3,2-C] quinoline-based fluorescent probe DNA2, IRF3, DDB1 MEN1 3101/4885KMT2A 3767/4885RAD51 1360/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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