Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PADI4 | Q9UM07 | 8/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18960700 | 0.89 | PADI4 (0.65) | PADI4 | |
| SCHEMBL22450566 | 0.88 | PADI4 (0.47) | PADI4HPGD | |
| SCHEMBL18975348 | 0.86 | PADI4 (0.59) | PADI4 | |
| SCHEMBL18960747 | 0.84 | PADI4 (0.51) | PADI4 | |
| SCHEMBL18960746 | 0.84 | PADI4 (0.51) | PADI4 | |
| SCHEMBL18960749 | 0.84 | PADI4 (0.51) | PADI4 | |
| SCHEMBL18960702 | 0.83 | PADI4 (0.62) | PADI4 | |
| SCHEMBL22450519 | 0.79 | PADI4 (0.61) | PADI4 | |
| SCHEMBL22450554 | 0.79 | PADI4 (0.54) | PADI4TSHR | |
| SCHEMBL16817913 | 0.79 | PADI4 (0.81) | PADI4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3386505-B1 | AZA-BENZIMIDAZOLE INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS INC (US) | 2020-09-23 | — | — | EP | disclosed |