Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | PPOX | P50336 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.55 |
| ▸ | TAS2R14 | Q9NYV8 | 10/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.52 |
| ▸ | PNLIP | P16233 | 1/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | PARG | Q86W56 | 1/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.49 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22453592 | 0.89 | MRGPRX4 (0.53) | MEN1KMT2ATTRPPOXTDP1 | |
| SCHEMBL22452471 | 0.86 | MEN1 (0.63) | MEN1KMT2ATTRPPOXTDP1 | |
| SCHEMBL4245559 | 0.80 | MAPK8 (0.67) | MEN1KMT2ATAS2R14ALDH1A1MAPT | |
| SCHEMBL10875248 | 0.80 | MEN1 (0.56) | MEN1KMT2AALDH1A1MAPTMRGPRX4 | |
| SCHEMBL22453595 | 0.80 | KMT2A (0.51) | MEN1KMT2ATTRPPOXTDP1 | |
| Anthracene SCHEMBL7269976 | 0.80 | MAPK8 (0.63) | MEN1KMT2ATAS2R14ALDH1A1MAPT | |
| SCHEMBL10924171 | 0.80 | CCR1 (0.60) | MEN1KMT2ATTRPPOXTDP1 | |
| SCHEMBL6290662 | 0.78 | MEN1 (0.72) | MEN1KMT2ATTRPPOXTDP1 | |
| SCHEMBL11243867 | 0.78 | MEN1 (0.72) | MEN1KMT2ATTRPPOXTDP1 | |
| SCHEMBL10997932 | 0.78 | FFAR1 (0.67) | MEN1KMT2ATTRPPOXTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |