Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | SCN8A | Q9UQD0 | 2/20 | 0.50 |
| ▸ | SCN10A | Q9Y5Y9 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.49 |
| ▸ | TTR | P02766 | 1/20 | 0.48 |
| ▸ | PPOX | P50336 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.48 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.48 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | PNLIP | P16233 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452471 | 0.92 | MEN1 (0.63) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL22453592 | 0.88 | MRGPRX4 (0.53) | KMT2AMAPTMEN1KDM4EFFAR1 | |
| SCHEMBL22452912 | 0.88 | KMT2A (0.52) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL11212618 | 0.85 | TDP1 (0.54) | KMT2AMAPTMEN1SCN8ASCN10A | |
| SCHEMBL11212778 | 0.83 | TDP1 (0.57) | KMT2AMAPTMEN1LMNASCN8A | |
| SCHEMBL22452952 | 0.83 | MAPT (0.51) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL22453402 | 0.83 | MAPT (0.51) | KMT2AMAPTMEN1LMNAPOLB | |
| SCHEMBL11238106 | 0.82 | TDP1 (0.58) | KMT2AMAPTMEN1SCN8ASCN10A | |
| SCHEMBL29448825 | 0.82 | TDP1 (0.58) | KMT2AMAPTMEN1SCN8ASCN10A | |
| SCHEMBL11854430 | 0.82 | TDP1 (0.58) | KMT2AMAPTMEN1SCN8ASCN10A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |