Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 3/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 11/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MDH1 | P40925 | 1/20 | 0.39 |
| ▸ | MDH2 | P40926 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452479 | 0.94 | EPHX2 (0.50) | EPHX2HIF1AEPAS1NPC1SIRT2 | |
| SCHEMBL22453625 | 0.89 | EPHX2 (0.45) | EPHX2HIF1AEPAS1NPC1SIRT2 | |
| SCHEMBL22452502 | 0.87 | HIF1A (0.54) | EPHX2HIF1AEPAS1NPC1SIRT2 | |
| SCHEMBL22452501 | 0.86 | MAPT (0.55) | EPHX2HIF1AEPAS1NPC1MDH1 | |
| SCHEMBL22452498 | 0.81 | HIF1A (0.60) | EPHX2HIF1AEPAS1NPC1MAPT | |
| SCHEMBL31555348 | 0.81 | HIF1A (0.60) | EPHX2HIF1AEPAS1NPC1MAPT | |
| SCHEMBL22452503 | 0.80 | MAPT (0.58) | EPHX2HIF1AEPAS1NPC1MDH1 | |
| SCHEMBL23591772 | 0.78 | EPHX2 (0.54) | EPHX2HIF1AEPAS1NPC1MAPT | |
| SCHEMBL22452850 | 0.77 | HIF1A (0.52) | EPHX2HIF1AEPAS1NPC1MAPT | |
| SCHEMBL22452485 | 0.77 | EPHX2 (0.52) | EPHX2HIF1AEPAS1NPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |