Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.48 |
| ▸ | MDH1 | P40925 | 2/20 | 0.48 |
| ▸ | MDH2 | P40926 | 2/20 | 0.48 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | EP300 | Q09472 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452503 | 0.94 | MAPT (0.58) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452848 | 0.91 | MAPT (0.49) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452612 | 0.88 | MAPT (0.46) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22453226 | 0.88 | HIF1A (0.53) | MAPTHIF1AEPAS1MDH1MDH2 | |
| SCHEMBL22452652 | 0.88 | EPHX2 (0.61) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452507 | 0.88 | MAPT (0.53) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452502 | 0.88 | HIF1A (0.54) | MAPTHIF1AEPAS1EPHX2NPC1 | |
| SCHEMBL22453773 | 0.86 | HIF1A (0.45) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22452506 | 0.86 | EPHX2 (0.46) | MAPTALOX15HIF1AEPAS1MDH1 | |
| SCHEMBL22453525 | 0.85 | MAPT (0.50) | MAPTALOX15HIF1AEPAS1MDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |