Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 9/20 | 0.39 |
| ▸ | EPAS1 | Q99814 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | MDH1 | P40925 | 2/20 | 0.37 |
| ▸ | MDH2 | P40926 | 2/20 | 0.37 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | EP300 | Q09472 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452747 | 0.92 | SERPINE1 (0.41) | HIF1AEPAS1HTTLMNAGAA | |
| SCHEMBL22452574 | 0.92 | CNR2 (0.41) | CNR2HIF1AEPAS1LMNAMDH1 | |
| SCHEMBL22452580 | 0.86 | CNR2 (0.52) | CNR2HIF1AEPAS1HTTLMNA | |
| SCHEMBL22452697 | 0.83 | SERPINE1 (0.41) | HIF1AEPAS1HTTLMNAGAA | |
| SCHEMBL22452628 | 0.83 | CNR2 (0.47) | CNR2HIF1AEPAS1HTTLMNA | |
| SCHEMBL22453117 | 0.82 | CNR2 (0.53) | CNR2HIF1AEPAS1HTTGAA | |
| SCHEMBL22453494 | 0.81 | CNR2 (0.56) | CNR2HIF1AEPAS1LMNAMDH1 | |
| SCHEMBL22453152 | 0.80 | CNR2 (0.47) | CNR2HIF1AEPAS1HTTLMNA | |
| SCHEMBL22452627 | 0.80 | CNR2 (0.51) | CNR2HIF1AEPAS1HTTLMNA | |
| SCHEMBL22452973 | 0.79 | CNR2 (0.40) | CNR2HIF1AEPAS1LMNAMDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |