Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 5/20 | 0.37 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | PKM | P14618 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | TTR | P02766 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452579 | 0.92 | CNR2 (0.40) | SERPINE1LMNAHTTMAPTGAA | |
| SCHEMBL22452697 | 0.92 | SERPINE1 (0.41) | SERPINE1LMNAHTTMAPTGAA | |
| SCHEMBL22452744 | 0.85 | SERPINE1 (0.38) | SERPINE1LMNAHTTMAPTGAA | |
| SCHEMBL22453002 | 0.84 | DHODH (0.50) | SERPINE1LMNAHTTMAPTNPSR1 | |
| SCHEMBL22452574 | 0.83 | CNR2 (0.41) | SERPINE1LMNADHODHHIF1AEPAS1 | |
| SCHEMBL22453012 | 0.82 | LTC4S (0.39) | SERPINE1LMNAHTTMAPTGAA | |
| SCHEMBL22453245 | 0.81 | LTC4S (0.41) | SERPINE1LMNAHTTMAPTGAA | |
| SCHEMBL22453641 | 0.80 | DHODH (0.55) | SERPINE1LMNAHTTMAPTNPSR1 | |
| SCHEMBL22453241 | 0.79 | NPC1 (0.44) | SERPINE1LMNAHTTMAPTGAA | |
| SCHEMBL22453640 | 0.79 | DHODH (0.57) | SERPINE1LMNAMAPTGAADHODH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |