Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 6/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.48 |
| ▸ | EPAS1 | Q99814 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | MDH1 | P40925 | 1/20 | 0.44 |
| ▸ | MDH2 | P40926 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22452503 | 0.93 | MAPT (0.58) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22453221 | 0.90 | HIF1A (0.51) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22452577 | 0.90 | HIF1A (0.51) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22452507 | 0.89 | MAPT (0.53) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22452501 | 0.88 | MAPT (0.55) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22453247 | 0.87 | EPHX2 (0.65) | EPHX2MAPTNPC1HIF1AEPAS1 | |
| SCHEMBL22453739 | 0.86 | KDM4E (0.53) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22453658 | 0.85 | MAPT (0.49) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22452848 | 0.85 | MAPT (0.49) | EPHX2MAPTALOX15NPC1HIF1A | |
| SCHEMBL22453751 | 0.85 | HPGD (0.55) | EPHX2MAPTNPC1HIF1AEPAS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020190774-A1 | NOVEL SMALL MOLECULE INHIBITORS OF TEAD TRANSCRIPTION FACTORS | THE GENERAL HOSPITAL CORPORATION (US) | 2020-09-24 | — | — | WO | disclosed |